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TranscriptomicsChromatin immunopreciptiation of human lymphoblastoid cells to identify histone H3K9/14 acetylation regions at common fragile sites
Map the histone H3K9/14 acetylation regions of in human cells at 7 common fragile sites and their flanking non-fragile sequences as well as a 200kb containing the rare fragile site FRAXA, a 1,075kb non-fragile region on chr22, a hyperacetylated region HALPHA44, and a heterochromatic region HET405. T...
ORGANISM(S): Homo sapiens 
2009-10-07 | E-TABM-347 | biostudies-arrayexpress
ProteomicsProteomics characterization of Chromosomal Common Fragile Site (CFS) - associated proteins uncovers ATRX as a regulator of CFS stability
Chromosomal Common Fragile Sites (CFSs) are conserved regions of our genome prone to break in conditions of replication stress (RS. Here, we have performed Chromatin Immunoprecipitation (ChIP) with FACND2 antibodies coupled to Mass Spectrometry to isolate CFSs from HeLa cells and identify the protei...
ORGANISM(S): Homo sapiens (Human) 
2019-06-11 | PXD011937 | Pride
Common fragile sites Hela Atrx Interactome Lc-ms/ms 
TranscriptomicsChromatin immunopreciptiation of human lymphoblastoid untreated and treated with aphidicolin (APH), trichostatin A (TSA), or APH plus TSA cells to map the origins of DNA replication at common fragile sites
Map the origins of DNA replication in human cells at 7 common fragile sites and their flanking non-fragile sequences as well as a 200kb containing the rare fragile site FRAXA, and a 1,075kb non-fragile region on chr22 . The origins were mapped in untreated cells, as well as, in cells treated with ap...
ORGANISM(S): Homo sapiens 
2010-02-27 | E-TABM-348 | biostudies-arrayexpress
GenomicsGenome-wide mapping of early replication fragile sites (ERFS)
DNA double strand breaks (DSBs) in B lymphocytes are thought to arise stochastically during replication (S phase) or as a result of targeted DNA damage by activation induced cytidine deaminase (AID) in G1. Here we identify a novel class of recurrent, early replicating and AID independent DNA lesi...
ORGANISM(S): Mus musculus 
2013-02-04 | E-GEOD-43504 | biostudies-arrayexpress
GenomicsGenome-wide High Resolution Mapping of Mitotic DNA Synthesis Sites and Common Fragile Sites by Direct Sequencing [WGS]
Genome-wide High Resolution Mapping of Mitotic DNA Synthesis Sites and Common Fragile Sites by Direct Sequencing [WGS]
PRJNA628519 | ENA
GenomicsGenome-wide High Resolution Mapping of Mitotic DNA Synthesis Sites and Common Fragile Sites by Direct Sequencing [MiDA-seq]
Genome-wide High Resolution Mapping of Mitotic DNA Synthesis Sites and Common Fragile Sites by Direct Sequencing [MiDA-seq]
PRJNA628521 | ENA
GenomicsGenome-wide High Resolution Mapping of Mitotic DNA Synthesis Sites and Common Fragile Sites by Direct Sequencing [RNA-seq]
Genome-wide High Resolution Mapping of Mitotic DNA Synthesis Sites and Common Fragile Sites by Direct Sequencing [RNA-seq]
PRJNA628520 | ENA
UnknownMolecular basis for expression of common and rare fragile sites.
Not available
S-EPMC230307 | biostudies-literature
UnknownInhibition of topoisomerase I prevents chromosome breakage at common fragile sites.
Not available
S-EPMC2896008 | biostudies-literature
OtherGenome-wide High Resolution Mapping of Mitotic DNA Synthesis Sites and Common Fragile Sites by Direct Sequencing [WGS]
Common fragile sites (CFSs) are genomic loci prone to the formation of breaks or gaps on metaphase chromosomes. Here, we seek to map human CFSs with high resolution on a genome-wide scale by sequencing the sites of mitotic DNA synthesis (MiDASeq) that are specific for CFSs. We generated a nucleotide...
ORGANISM(S): Homo sapiens 
2020-05-01 | GSE149375 | GEO
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