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ProteomicsCompetitive target ID for inhibitor NK192
Competitive target ID for inhibitor NK192. To this end the inhibitor was decorated with biotin and used in a pull-down experiment to pull out the desired on-target (USP7) and possible off-targets. The samples were analysed by LC-MS.
ORGANISM(S): Homo sapiens (Human) 
2026-04-21 | PXD063889 | Pride
Usp7 Lc-ms Pull-down 
ProteomicsDetection of Dichlorvos Aducts in Hepatocyte Cell Line LC-MS/MS
Toxicity of dichlorvos (DDVP), an organophosphate (OP) pesticide, classically results from modification of the serine in the active sites of cholinesterases. However, DDVP also forms adducts on unrelated targets such as transferrin and albumin, suggesting that DDVP causes cellular perturbation by mo...
ORGANISM(S): Homo sapiens (Human) 
2014-07-31 | PXD001107 | Pride
Hepatocyte cell line Dichorvos Lc-ms/ms 
ProteomicsSelective Arylation of Selenocysteine of Thioredoxin Reductase 1 by an Organogold Compound: Expanding the Tool-Box of Metal-Templated Reactions in Cancer Cells – pull-down
Cyclometalated gold(III) complexes have been reported to template C-S cross-coupling reactions in a biological environment and acting as modifies of cysteine residues. To broaden the scope of organogold complexes for covalent protein post-translational modification in cancer cells, an oxime-containi...
ORGANISM(S): Homo sapiens (Human) 
2025-04-22 | PXD044971 | Pride
Arylation ∙ cancer ∙ chemoproteomics ∙ gold ∙ metals in medicine ∙ selenoprotein ∙ thioredoxin reductase 1 
ProteomicsMS analysis of cellular targets of an engineered selective PSD-95 PDZ domain ligand
Designing highly specific modulators of protein-protein interactions (PPIs) is especially challenging in the context of multiple paralogs and conserved interaction surfaces. In this case, direct generation of selective and competitive inhibitors is hindered by high similarity within the evolutionary...
ORGANISM(S): Rattus norvegicus (Rat) 
2019-11-12 | PXD015313 | Pride
Engineered ligand/pdz domains/pull-down 
ProteomicsTargeting the Scaffold Protein Plectin by an Organometallic as a Strategy to Inhibit Tumour Invasiveness- whole cell lysate of HCT 116 epithelial cells, Ru-OH-2 competitive pull down 4h
The inability of determining direct molecular targets of metal-based therapeutic agents beyond the platinum class is one of the major bottlenecks in their development. Here, we employ an integrated chemical proteomics and response profiling approach to identify and validate plestatins, based on an o...
ORGANISM(S): Homo sapiens (Human) 
2022-03-01 | PXD010319 | Pride
Ruthenium Response profiling Organometallics Target identification Metallodrugs Chemical proteomics Mechanism of action Plectin 
UnknownEvolutionary comparison of competitive protein-complex formation of MYB, bHLH, and WDR proteins in plants.
Not available
S-EPMC6598095 | biostudies-literature
ProteomicsComprehensive Structure-Activity Profiling of Micheliolide and its Targeted Proteome in Leukemia Cells via Probe-Guided Late-Stage C—H Functionalization
The plant-derived sesquiterpene lactone micheliolide was recently found to possess promising antileukemic activity, including the ability to target and kill leukemia stem cells. Efforts toward improving the biological activity of micheliolide and investigating its mechanism of action have been hinde...
ORGANISM(S): Homo sapiens (Human) 
2021-09-10 | PXD024455 | Pride
Competitive pull-down Multi-probe proteomics Leukemia stem cells C-h functionalization Biocatalysis Sesquiterpene lactones 
UnknownFisetin is a selective adenosine triphosphate-competitive inhibitor for mitogen-activated protein kinase kinase 4 to inhibit lipopolysaccharide-stimulated inflammation.
Not available
S-EPMC11680972 | biostudies-literature
UnknownThe lnc-CTSLP8 upregulates CTSL1 as a competitive endogenous RNA and promotes ovarian cancer metastasis.
Not available
S-EPMC8088648 | biostudies-literature
ProteomicsTargeting the Scaffold Protein Plectin by an Organometallic as a Strategy to Inhibit Tumour Invasiveness- whole cell lysate of HCT 116 epithelial cells, plestatins-3 competitive pull down 19h
The inability of determining direct molecular targets of metal-based therapeutic agents beyond the platinum class is one of the major bottlenecks in their development. Here, we employ an integrated chemical proteomics and response profiling approach to identify and validate plestatins, based on an o...
ORGANISM(S): Homo sapiens (Human) 
2022-03-01 | PXD005388 | Pride
Ruthenium Response profiling Organometallics Target identification Metallodrugs Chemical proteomics Mechanism of action Plectin 
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