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MetabolomicsElectroacupuncture at Ll11 and SP10 is associated with alleviation of acute urticaria-like reactions in passive cutaneous anaphylaxis: an exploratory analysis of complement-related proteins and multiscale omics

Background: The lifetime prevalence of acute urticaria is approximately 20%. Although electroacupuncture (EA) has been investigated as an adjunctive treatment for urticaria, the molecular mechanisms underlying these effects remain elusive. Passive cutaneous anaphylaxis (PCA) serves as an experime...

2026-06-03 | MTBLS14327 | MetaboLights
TranscriptomicsRNA-seq of intestinal organoids treated with the complement C5a receptor 1 (C5aR1) antagonist PMX205 with or without irradiation
In this project, we aimed to examine gene expression changes in intestinal organoids treated with the complement C5a receptor 1 (C5aR1) antagonist PMX205 either with or without irradiation. Intestinal organoids from wild-type C57BL/6 mice were cultured and plated. The following day, the media was su...
ORGANISM(S): Mus musculus 
2023-01-25 | E-MTAB-12548 | biostudies-arrayexpress
GenomicsComplement C5a/C5a receptor 1 induces renal injury in diabetic kidney disease via mitochondrial metabolic reprogramming
Complement C5a/C5a receptor 1 induces renal injury in diabetic kidney disease via mitochondrial metabolic reprogramming
PRJNA484388 | ENA
TranscriptomicsRegulation of neuronal gene and miRNA expression by the complement protein C1q associated with neuroprotection
Identification of transcriptional profiles stimulated by the complement protein C1q in rat immature neurons associated with the C1q-dependent neuroprotection observed in vitro. Use of the unbiased whole genome microarray approach to identify genes regulated by C1q. Immature neurons grown in vitro fo...
ORGANISM(S): Rattus norvegicus 
2011-03-07 | E-GEOD-18860 | biostudies-arrayexpress
GenomicsExpression data from primary human neutrophils incubated with complement anaphylatoxin C5a
Expression data from primary human neutrophils incubated with complement anaphylatoxin C5a
PRJNA634018 | ENA
ProteomicsComplement C5a impairs phagosomal maturation in the neutrophil through phosphoproteomic remodelling.
Critical illness is characterised by organ failure, dysregulated immune activation and frequent secondary infections. Unbridled complement activation in these patients exposes immune cells to high levels of the anaphylotoxin, C5a. C5a suppresses antimicrobial functions of key immune cells, in partic...
ORGANISM(S): Homo sapiens (Human) 
2020-08-06 | PXD017092 | Pride
Critical care Neutrophils Staphylococcus aureus Complement system proteins Phosphoproteome 
TranscriptomicsExpression data from primary human neutrophils incubated with complement anaphylatoxin C5a
Influence of complement anaphylatoxin C5a on neutrophil gene expression Trauma causes an early activation of the complement system, which leads to excessive generation of the anaphylatoxin C5a. Furthermoren, alterations in neutrophil function are often associated with infectious complication after t...
ORGANISM(S): Homo sapiens 
2020-09-23 | GSE150902 | GEO
TranscriptomicsComplement C5a/C5a receptor 1 induces renal injury in diabetic kidney disease via mitochondrial metabolic reprogramming
In mice, complement C5a and its receptor C5aR1 elicit systemic and local inflammation and drive tissue injury in diabetic kidney disease via altered metabolic flexibility, which can be attenuated by therapy with a specific orally active inhibitor of C5aR1.
ORGANISM(S): Mus musculus 
2019-07-01 | GSE118089 | GEO
UnknownComplement C5a-Induced Changes in Neutrophil Morphology During Inflammation.
Not available
S-EPMC5773343 | biostudies-literature
UnknownComplement Factor C5a Inhibits Apoptosis of Neutrophils-A Mechanism in Polytrauma?
Not available
S-EPMC8303460 | biostudies-literature
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