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ProteomicsGlycoproteomic and genetic analysis of N-glycosylation of complement component C3 reveals immune pathway regulation
This dataset comprises site-specific glycopeptide analysis of complement component C3 from plasma samples of 816 adults from the Korčula cohort (Croatia). C3 glycopeptides were enriched using Concanavalin A lectin affinity chromatography and analyzed by nano-LC-MS/MS. The study characterizes the N-g...
ORGANISM(S): Homo sapiens (Human) 
2026-05-30 | PXD074569 | Pride
Glycoproteomics Complement c3 High-mannose glycans N-glycosylation 
ProteomicsN-glycosylation analysis of human complement component C3 LC-MS - annotation data
The most abundant and central component, glycoprotein C3, contributes to the development of type 1 diabetes by enhancing the organ-specific autoimmune inflammatory processes. It is known that changes in glycosylation can modulate inflammatory responses and we recently showed that children at the ons...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD035126 | Pride
Complement c3 
ProteomicsComplement C3 deposition on nucleic acids is characteristic of immune complex initiated classical pathway overdrive in lupus erythematosus
Systemic lupus erythematosus is progressive, immune complex-mediated autoimmune disease targeting numerous organs. A central feature of the disease is the development of antibodies against nuclear components, including DNA. Antibodies against double-stranded DNA are so characteristic of this disease...
ORGANISM(S): Homo sapiens 
2012-09-30 | E-GEOD-26768 | biostudies-arrayexpress
TranscriptomicsRepeated systemic challenge with lipopolysaccharides induces dopaminergic neurodegeneration in the brain by activation of the complement-phagosome pathway
Systemic inflammatory reactions mediated by chronic infections activate microglia in the central nervous system (CNS) and have been postulated to exacerbate neurodegenerative diseases. We now demonstrate in vivo that repeated systemic challenge of mice with bacterial lipopolysaccharides (LPS) mainta...
ORGANISM(S): Mus musculus 
2014-07-11 | E-MTAB-1770 | biostudies-arrayexpress
MetabolomicsElectroacupuncture at Ll11 and SP10 is associated with alleviation of acute urticaria-like reactions in passive cutaneous anaphylaxis: an exploratory analysis of complement-related proteins and multiscale omics

Background: The lifetime prevalence of acute urticaria is approximately 20%. Although electroacupuncture (EA) has been investigated as an adjunctive treatment for urticaria, the molecular mechanisms underlying these effects remain elusive. Passive cutaneous anaphylaxis (PCA) serves as an experime...

2026-06-03 | MTBLS14327 | MetaboLights
ProteomicsN-glycosylation analysis of human complement component C3 LC-MS
The most abundant and central component, glycoprotein C3, contributes to the development of type 1 diabetes by enhancing the organ-specific autoimmune inflammatory processes. It is known that changes in glycosylation can modulate inflammatory responses and we recently showed that children at the ons...
ORGANISM(S): Homo sapiens (Human) 
2023-03-10 | PXD034083 | Pride
Lc-ms c3 
TranscriptomicsRegulation of neuronal gene and miRNA expression by the complement protein C1q associated with neuroprotection
Identification of transcriptional profiles stimulated by the complement protein C1q in rat immature neurons associated with the C1q-dependent neuroprotection observed in vitro. Use of the unbiased whole genome microarray approach to identify genes regulated by C1q. Immature neurons grown in vitro fo...
ORGANISM(S): Rattus norvegicus 
2011-03-07 | E-GEOD-18860 | biostudies-arrayexpress
TranscriptomicsThe alternative complement pathway appears to be a UVA sensor that leads to systemic immunosuppression
Ultraviolet (UV) wavebands in sunlight are immunomodulatory. About half the amount of UVA within a minimum erythemal dose of sunlight is systemically immunosuppressive, while higher doses protect from UVB immunosuppression in mice. We have previously shown that these responses to UVA are genetically...
ORGANISM(S): Mus musculus 
2010-05-16 | E-GEOD-15618 | biostudies-arrayexpress
ProteomicsUrine complement analysis implies complement activation is involved in membranous nephropathy
Total 1,427 differentially expressed proteins were identified between the MN and HC groups. KEGG pathway analysis showed significant enrichment of these DEPs in the complement-activated pathway within the MN group. Additionally, a correlation was found between proteinuria and the levels of 27 urinar...
ORGANISM(S): Homo Sapiens 
2025-02-01 | PXD060494 |
ProteomicsProteomic Analysis of Urinary Extracellular Vesicles
Novel therapies in autosomal dominant polycystic kidney disease (ADPKD) signal the need for markers of disease progression or response to therapy. This study aimed to identify disease-associated proteins in urinary extracellular vesicles (uEVs), which include exosomes, in patients with ADPKD. We per...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-10-21 | MSV000080264 | MassIVE
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