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ProteomicsPPR proteins in Arabidopsis mitoribosomes
Investigation of the protein composition of mitoribosomal subunits in Arabidopsis thaliana by complexome profiling
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2019-04-30 | PXD011088 | Pride
Mitoribosomal subunits Ppr proteins Mitoribosomes Complexome profiling 
ProteomicsProtein exchange rates within mitochondrial protein complexes of differentiated myotubes using pulsed SILAC complexome profiling
We studied dynamics within stable mitochondrial complexes in differentiated mouse myotubes by pulsed SILAC complexome profiling.
ORGANISM(S): Mus musculus (Mouse) 
2020-03-05 | PXD017465 | Pride
Complex i Mitochondria Lc-msms Complexome profiling 
ProteomicsComplexome profiling of mitochondrial protein complexes from patients with mutation in NDUFAF8 gene
NDUFAF8 is an assembly factor of the NADH:ubiquinone oxidoreductase (complex I). Here we used complexome profiling the functional consequences of NDUFAF8 mutations in patient fibroblasts.
ORGANISM(S): Homo sapiens (Human) 
2020-03-05 | PXD015749 | Pride
Oxidative phosphorylation system Lc-msms Complexome profiling Complex i assembly 
ProteomicsComplexome profiling of mitochondrial protein complexes from patients with mutation in NDUFC2 gene
NDUFC2 is a subunit of the membrane part of NADH:ubiquinone oxidoreductase (complex I). Here we used complexome profiling to study the role of NDUFC2 in complex I stability and assembly.
ORGANISM(S): Homo sapiens (Human) 
2020-08-10 | PXD014936 | Pride
Oxidative phosphorylation system Lc-msms Complexome profiling Complex i assembly 
ProteomicsMultiplexed complexome profiling using tandem mass tags
Complexome profiling is a rapidly spreading, powerful approach to gain insight into the nature of protein complexes. It identifies and quantifies protein complexes separated into multiple fractions of increasing molecular mass using mass spectrometry-based, label-free bottom-up proteomics. Complexom...
ORGANISM(S): Homo sapiens (Human) 
2021-08-20 | PXD023211 | Pride
Complexome profiling  multiplexed complexomics  tandem mass tags  protein complexes 
ProteomicsComplexome profiling of mitochondrial protein complexes to study assembly and stability of complex I in a patient with a defect in the NDUFAF3 gene
NDUFAF3 is a factor required for the coordinated assembly of the first complex of the oxidative phosphorylation system (OXPHOS). Here we used a complexome profiling of fibroblasts from a patient to analyze the consequence of a mutation in the NDUFAF3 gene on the molecular level.
ORGANISM(S): Homo sapiens (Human) 
2023-08-21 | PXD037757 | Pride
Oxidative phosphorylation system Supercomplexes Lc-msms Complexome profiling 
ProteomicsComplexome profiling of mitochondrial protein complexes from patients with mutations in either DNAJC30 or ACAD9 compared to an age and gender matched control
We identified the chaperone DNAJC30 as an important factor to maintain NADH:ubiquinone oxidoreductase (complex I) activity. To determine whether DNAJC30 acts as a complex I assembly factor, we used complexome profiling to compare the molecular consequences of DNAJC30 mutations in contrast to defects...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD021386 | Pride
Oxidative phosphorylation system Lc-msms Complexome profiling Complex i maintenance Complex i assembly 
ProteomicsDynamic complexome profiling identifies impaired turnover of specific complex I subunits in a patient with mutations in DNAJC30.
We identified DNAJC30 as a key protein in the maintenance of functional NADH:ubiquinone oxidoreductase (complex I). To determine the turnover rates of modules in complex I, we pulsed patient and control fibroblast cell lines over 12 hours with heavy amino acids (PulseSILAC) followed by dynamic compl...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD021499 | Pride
Oxidative phosphorylation system Protein turnover Lc-msms Complexome profiling Complex i maintenance Complex i assembly 
ProteomicsComplexome Profiling of the thylakoid proteome from Arabidopsis thaliana
We here present an investigation of the Arabidopsis thaliana energy metabolism taking place in the chloroplasts. Thylakoids were purified from Arabidopsis thaliana leaves and membrane bound protein complexes characterized by Blue native polyacrylamide gel electrophoresis as well as by the complexome...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2022-08-18 | PXD035871 | Pride
Arabidopsis thaliana Proteome Thylakoids Lc-msms Blue native 
ProteomicsComplexome profiling to study assembly of complex III in heart tissue from UQCRH deficient mice
UQCRH, also called the hinge protein, is a small subunit of Ubiquinol—cytochrome-c reductase (complex III). Here we used a complexome analysis of heart tissue of UQCRH deficient mice to study complex III assembly and altered supercomplex composition.
ORGANISM(S): Mus musculus (Mouse) 
2021-09-20 | PXD022855 | Pride
Oxidative phosphorylation system Supercomplex formation and stability Complexome profiling Complex iii assembly 
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