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GenomicsGenome-wide T. brucei RNAi screen with compound 25
Genome-wide T. brucei RNAi screen with compound 25
PRJEB38509 | ENA
ProteomicsCompound interaction screen on a photoactivatable cellulose membrane (CISCM) identifies drug targets
Here, we present a compound interaction screen on a photoactivatable cellulose membrane (CISCM) that enables target identification of several drugs in parallel. To this end, we use diazirine-based undirected photoaffinity labeling (PAL) to immobilize compounds on cellulose membranes. Functionalized ...
ORGANISM(S): Homo sapiens (Human) 
2022-10-25 | PXD033050 | Pride
Human affinity purification-mass spectrometry samples 
TranscriptomicsIn vivo screen of Francisella tularensis subsp. novicida mutants in sequence defined transposon library
We used an inhalation mouse model of infection to query a collection of 2149 mutants in a Francisella tularensis subsp. novicida background for genes required for growth, survival and systemic dissemination. A microarray-based genome-wide negative selection screen (Microarray tracking of transposon ...
ORGANISM(S): Francisella tularensis subsp. novicida 
2008-12-30 | E-GEOD-11297 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of serum microRNAs in rat livers to screen for specific biomarkers to be used in diagnosis of compound- and herb-induced liver injury.
In this study, we employed a strategy to screen miRNA expression profiles in liver tissue by miRCURY LNA(tm) microRNA array analysis followed by TaqMan probe-based quantitative reverse transcription-PCR (qRT-PCR) to validate the miRNA expression profiles in serum and liver of two parallel rat drug-i...
ORGANISM(S): Rattus norvegicus 
2012-09-08 | E-MEXP-3364 | biostudies-arrayexpress
GenomicsOxidosqualene cyclase targeting compound in Leishmania
Overexpression library screen - Oxidosqualene cyclase targeting compound in Leishmania donovani
PRJEB37256 | ENA
TranscriptomicsHigh throughput screening for chemical inducers of stumpy formation in Trypanosoma brucei
During the bloodstream stage of the Trypanosoma brucei lifecycle, the parasite exists as the proliferative slender-form or the non-proliferative, transmissible, stumpy-form. The transition from the slender to stumpy-form is stimulated by a density-dependent mechanism and is important in infection dy...
ORGANISM(S): Trypanosoma brucei brucei 
2014-01-21 | E-GEOD-46483 | biostudies-arrayexpress
TranscriptomicsTOV112D cells treated with NSC319726
Rescuing the function of mutant p53 protein is an attractive cancer therapeutic strategy. Using the NCI anticancer drug screen data, we identified two compounds from the thiosemicarbazone family that manifest increased growth inhibitory activity in mutant p53 cells, particularly for the p53R175 muta...
ORGANISM(S): Homo sapiens 
2012-02-22 | E-GEOD-35972 | biostudies-arrayexpress
ProteomicsA cell competition-based drug screen identifies a novel compound that induces dual c-Myc degradation and p53 activation
BCR-Abl is a driver oncogene that causes chronic myeloid leukemia and a subset of acute lymphoid leukemias. Although tyrosine kinase inhibitors provide an effective treatment for these diseases, they generally do not kill leukemic stem cells. Leukemic stem cells are cancer-initiating cells that comp...
ORGANISM(S): Mus musculus (Mouse) 
2020-12-07 | PXD018812 | Pride
Leukemia C-myc Drug screening Anticancer drug Abl tyrosine kinase Phosphoproteomics Mrna P53 
GenomicsZebrafish chemical compound screen uncovers inducers of skeletal muscle engraftment across species
Zebrafish chemical compound screen uncovers inducers of skeletal muscle engraftment across species
PRJNA601746 | ENA
ProteomicsHSP90 promotes Burkitt lymphoma cell survival by maintaining tonic B cell receptor signaling
Burkitt’s lymphoma (BL) is an aggressive B-cell neoplasm that is currently treated by intensive chemotherapy in combination with anti-CD20 antibodies. Because of their toxicity, current treatment regimens are often not suitable for elderly patients or for patients in developing countries where BL is...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080781 | MassIVE
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