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MetabolomicsDNA nanomachines reveal an adaptive energy mode in confinement-induced amoeboid migration powered by polarized mitochondrial distribution

Energy metabolism is highly interdependent with adaptive cell migration in vivo. Mechanical confinement is a critical physical cue that induces switchable migration modes of the mesenchymal-to-amoeboid transition (MAT). However, the energy states in distinct migration modes, especially a...

2024-03-25 | MTBLS9657 | MetaboLights
TranscriptomicsFine control of nuclear confinement identifies a threshold deformation leading to lamina rupture and induction of specific genes
The quest to understand how the mechanical and geometrical environment of cells impacts their behaviour and fate has been a major force driving the recent development of new technologies in cell biology research. Despite rapid advances in this field, many challenges remain in order to bridge the gap...
ORGANISM(S): Homo sapiens 
2018-10-31 | E-MTAB-7339 | biostudies-arrayexpress
Proteomics3D confinement physically regulates cell cycle progression in budding yeast
Our understanding of cell division control traditionally comes via using liquid broths or 2D flat-plate cultures - which cannot recapitulate the complex visco-elasto-plastic properties of natural habitats such as tissues, mucus, and soil. Consequently, how such regimes of physical confinement influe...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2026-09-17 | PXD082794 | Pride
Confinement Cell cycle Yeast 
ProteomicsMitochondrial fuels ATP in the nucleus to prevent cell cycle arrest during mechanical confinement
Abstract The physical microenvironment regulates cell behaviour during tissue development and disease. Whether mechanical stress and physical space constraints reshape the subcellular localization of organelles and proteins resulting in functional adaptations is, however, unknown. Here, we performed...
ORGANISM(S): Homo sapiens (Human) 
2025-06-12 | PXD043524 | Pride
Confinement Nuclear atp Mitochondria Cell cycle Nucleus Dna damage 
TranscriptomicsConfinement stress in HR and LR trout lines
This SuperSeries is composed of the following subset Series: GSE25440: Individual variation in confinement response at 168h GSE25473: Time course study of confinement stress in HR and LR trout lines Refer to individual Series
ORGANISM(S): Oncorhynchus mykiss 
2010-11-24 | E-GEOD-25584 | biostudies-arrayexpress
ProteomicsMechanical confinement governs phenotypic plasticity in melanoma
Phenotype switching is a form of cellular plasticity in which cancer cells reversibly move between two opposite extremes - proliferative versus invasive states. While it has long been hypothesised that such switching is triggered by external cues, the identity of these cues has remained elusive. Her...
ORGANISM(S): Homo sapiens (Human) 
2025-08-26 | PXD060265 | Pride
Lc-ms Hmgb2 Melanoma 
TranscriptomicsTime course study of confinement stress in HR and LR trout lines
Farmed fish are unavoidably exposed to husbandry-related stressors which can result in outbreaks of disease, reduced reproductive success and poor growth. Biomarkers are needed for the establishment of selective breeding approaches for the production of stress resistant fish. In this context, microa...
ORGANISM(S): Oncorhynchus mykiss 
2010-11-24 | E-GEOD-25473 | biostudies-arrayexpress
TranscriptomicsIndividual variation in confinement response at 168h
Farmed fish are unavoidably exposed to husbandry-related stressors which can result in outbreaks of disease, reduced reproductive success and poor growth. Biomarkers are needed for the establishment of selective breeding approaches for the production of stress resistant fish. In this context, microa...
ORGANISM(S): Oncorhynchus mykiss 
2010-11-24 | E-GEOD-25440 | biostudies-arrayexpress
GenomicsMechanical confinement prevents ectopic platelet release
Mechanical confinement prevents ectopic platelet release
PRJNA1101070 | ENA
GenomicsMechanical confinement governs phenotypic plasticity in melanoma [HMGB2OE_RNAseq]
Mechanical confinement governs phenotypic plasticity in melanoma [HMGB2OE_RNAseq]
PRJNA1067146 | ENA
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