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MetabolomicsTranscript, protein and metabolite temporal dynamics in the CAM plant Agave
Already a proven mechanism for drought sustainability, crassulacean acid metabolism (CAM) is a specialized type of photosynthesis that maximizes water-use efficiency (WUE) via an inverse (compared to C3 and C4 photosynthesis-performing species) day/night pattern of stomatal closure/opening to shift ...
2017-10-13 | MTBLS363 | MetaboLights
ProteomicsConformational dynamics of the activated GLP-1 receptor-Gs complex revealed by cross-linking mass spectrometry and integrative modeling
Despite revolutionary advancements in GPCR structural biology, our understanding of the complexity of GPCR activation and signaling would not be complete without complementary information on the conformational dynamics. Yet it is particularly challenging to study the dynamics of GPCR complexes with ...
ORGANISM(S): Homo Sapiens 
2023-01-08 | PXD039315 |
ProteomicsDual Protease-Mediated Proteolysis Coupled with Ultrafiltration for System-Level Profiling of Drug Targets and Conformational Dynamics: cell level
Dual Protease-Mediated Proteolysis Coupled with Ultrafiltration for System-Level Profiling of Drug Targets and Conformational Dynamics
ORGANISM(S): Homo Sapiens 
2025-11-24 | PXD071125 |
GenomicsRNA tertiary structure and conformational dynamics revealed by BASH MaP
RNA tertiary structure and conformational dynamics revealed by BASH MaP
PRJNA1133698 | ENA
GenomicsConformational Dynamics in RNA Cleavage Specificity During Dicing
Conformational Dynamics in RNA Cleavage Specificity During Dicing
PRJNA1260926 | ENA
ProteomicsActivation loop phosphorylation tunes conformational dynamics underlying Pyk2 tyrosine kinase activation
Pyk2 is a multidomain non-receptor tyrosine kinase that undergoes a complex, multi-stage activation process. Ca2+-flux induces conformational rearrangements that relieve autoinhibitory FERM domain interactions. The kinase domain phosphorylates a key linker residue to recruit Src kinase. Pyk2 and Src...
ORGANISM(S): Homo sapiens (Human) 
2023-03-08 | PXD034028 | Pride
Kinase Phosphorylation Hdx-ms 
ProteomicsSubstrate-induced conformational dynamics of the dopamine transporter
The dopamine transporter is a member of the neurotransmitter:sodium symporters (NSSs), which are responsible for termination of neurotransmission through Na+-driven reuptake of neurotransmitter from the extracellular space. Experimental evidence elucidating the coordinated conformational rearrangeme...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2019-11-12 | PXD013841 | Pride
Ms  protein-ligand interactions  membrane proteins  mass spectrometry 
ProteomicsConformational dynamics of the human serotonin transporter during substrate and drug binding
The serotonin transporter (SERT), a member of the neurotransmitter:sodium symporter family, is responsible for termination of serotonergic signaling by re-uptake of serotonin (5-HT) into the presynaptic neuron. Its key role in synaptic transmission makes it a major drug target, e.g. for the treatmen...
ORGANISM(S): Homo sapiens (Human) 
2019-05-15 | PXD013750 | Pride
Hdx-ms  protein-ligand interactions  membrane proteins  mass spectrometry 
UnknownSubstrate-induced conformational dynamics of the dopamine transporter.
Not available
S-EPMC6586795 | biostudies-literature
UnknownConformational dynamics at the inner gate of KcsA during activation.
Not available
S-EPMC4010282 | biostudies-literature
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