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MetabolomicsGlycerophospholipid remodeling is critical for orthoflavivirus infection

Flavivirus infection is tightly connected to host lipid metabolism. Here, we performed shotgun lipidomics of cells infected with neurotropic Zika, West Nile and tick-borne encephalitis viruses, as well as dengue and yellow fever virus. Early in infection specific lipids accumulated, e.g., neutral...

2025-02-24 | MTBLS11030 | MetaboLights
MetabolomicsNMR-based metabolic profiling provides diagnostic and prognostic information in critically ill children with suspected infection

Sepsis, defined as life-threatening organ dysfunction caused by infection is difficult to distinguish clinically from infection or post-operative inflammation. We hypothesized that in a heterogeneous group of critically ill children, there would be different metabolic profiles between post-operat...

2020-11-19 | MTBLS563 | MetaboLights
TranscriptomicsFunctional exhaustion of fetal Th1 lymphocytes following congenital CMV infection - Huygens A. Marchant A.
Comparison of the transcriptome of naive (CD45RA+ CD27+) and differentiated (CD27-CD28-) CD4+ lymphocytes from newborns with congenital human cytomegalovirus infection (cord blood samples) and pregnant women diagnosed with primary CMV infection. Naive cells from HCMV uninfected newborns were used as...
ORGANISM(S): Homo sapiens 
2015-01-18 | E-MEXP-3473 | biostudies-arrayexpress
TranscriptomicsHuman induced pluripotent stem cell-technology to study the effects of human cytomegalovirus infection on neural differentiation
Congenital human cytomegalovirus (HCMV) infection is one of the leading prenatal causes of mental retardation and congenital deformities world-wide. Access to cultured human neuronal lineages, necessary to understand the species specific pathogenic effects of HCMV has been limited by difficulties i...
ORGANISM(S): Homo sapiens 
2013-01-04 | E-GEOD-35295 | biostudies-arrayexpress
MetabolomicsThe influence of canine parvovirus infection on the metabolome of captive Chinese and Malaysia pangolins
Canine parvovirus (CPV) infection poses a serious threat to pangolins, but the characteristics of the host response at the metabolic level remain unclear. In this study, we used non-targeted fecal metabolomics to systematically analyze differences in fecal metabolites in the Malaysian pangolin and t...
2026-08-22 | MTBLS15426 | MetaboLights
ProteomicsIdentification of new amniotic fluid prognostic biomarkers of congenital cytomegalovirus infection severity
Background: Congenital cytomegalovirus (cCMV) is a common intrauterine infection, leading to neurodevelopmental disabilities. Early prognostic assessment of the severity of cCMV has remained an ongoing challenge. We aimed to identify amniotic fluid biomarkers of the severity of cCMV-related fetal br...
ORGANISM(S): Homo sapiens (Human) Cytomegalovirus sp. 
2022-05-25 | PXD029105 | Pride
Cytomegalovirus  congenital cytomegalovirus infection  amniotic fluid biomarkers 
TranscriptomicsTranscriptional profile of PBMCs in patients with acute RSV or Influenza infection
To study the transcriptional profile of patients with acute RSV or Influenza infection,children of median age 2.4 months (range 1.5-8.6) hospitalized with acute RSV and influenza virus infection were offered study enrollment after microbiologic confirmation of the diagnosis. Blood samples were coll...
ORGANISM(S): Homo sapiens 
2012-03-12 | E-GEOD-34205 | biostudies-arrayexpress
ProteomicsHuman Cytomegalovirus modifies placental small extracellular vesicle secretion and composition to enhance infection of fetal recipient cells
Human cytomegalovirus (hCMV) primo-infection, reinfection and/or reactivation is a major issue during pregnancy and affects 1% of live births in western countries, making hCMV the most frequently transmitted virus in utero. Despite the extensive research conducted so far, the pathophysiology of this...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) Homo sapiens (Human) 
2022-10-13 | PXD029146 | Pride
Neural stem cells Hcmv Congenital infection Extracellular vesicles Placenta Cytotrophoblast 
UnknownParenting a child with congenital cytomegalovirus infection: a qualitative study.
Not available
S-EPMC7662527 | biostudies-literature
TranscriptomicsTranscriptome analysis of infection of the archaeon Sulfolobus solfataricus with STIV
Time series of infection of Sulfolobus solfataricus strain 2-2-12 cells infected with STIV are compared with uninfected cells over 32 h. Two-condition experiment, Control vs. Infected cells sampled at 5 time points (0, 8, 16, 24, 32 h post infection). Biological replicates: 3 control, 3 infected, pa...
ORGANISM(S): Sulfolobus solfataricus 
2008-07-25 | E-GEOD-12235 | biostudies-arrayexpress
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