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ProteomicsCell-specific analysis of tumour-endothelial contact-intiated signalling - PROTEOMICS
Metastasizing tumor cells exit the vascular system through dynamic interactions with endothelial cells that line the internal surface of vessels. While extravasation is a key event within the metastatic cascade, the signals regulating tumor cell adhesion to the endothelium and their subsequent trans...
ORGANISM(S): Homo sapiens (Human) 
2016-02-12 | PXD003048 | Pride
Epha2 Mda-mb-231-lm2 "contact-initiated signaling" Huvec 
ProteomicsCell-specific analysis of tumour-endothelial contact-intiated signalling
Tumour cell extravasation is a key event for metastatic colonisation1. However, little is known about the signalling pathways that govern tumour cell adhesion to the endothelium and subsequent transmigration through the blood vessel wall. Here, we combine Stable Isotope Labelling by Amino acids in C...
ORGANISM(S): Homo sapiens (Human) 
2016-02-12 | PXD001558 | Pride
Orbitrap velos Phospho Contact-initiated signalling Silac Transendothelial migration Mda-mb-231 Huvec 
TranscriptomicsExpression data from HMC-1 mast cells
We demonstrate that the G protein Gi3 is the cellular target of the adenosine A3 receptor (A3R). By using a cell permeable peptide comprising the C-terminal end of Gαi3 fused to an importation sequence (ALL1) as a selective inhibitor of Gi3 signaling, we show that by coupling to Gi3, the A3R stimu...
ORGANISM(S): Homo sapiens 
2010-04-12 | E-GEOD-19888 | biostudies-arrayexpress
UnknownObserving root growth and signalling responses to stress gradients and pathogens using the bi-directional dual-flow RootChip.
Not available
S-EPMC11563309 | biostudies-literature
TranscriptomicsTranscription profiling of Arabidopsis systemic response to avirulent bacterial infection
In the absence of adaptive immunity displayed by animals, plants respond locally to biotic challenge via inducible basal defense networks activated through recognition and response toconserved pathogen associated molecular patterns (PAMPs). In addition, immunity can be induced in tissues remote from...
ORGANISM(S): Arabidopsis thaliana 
2008-06-15 | E-GEOD-6831 | biostudies-arrayexpress
UnknownA phosphoinositide signalling pathway mediates rapid lysosomal repair.
Not available
S-EPMC9450835 | biostudies-literature
TranscriptomicsSystemic response to avirulent bacterial infection
In the absence of adaptive immunity displayed by animals, plants respond locally to biotic challenge via inducible basal defense networks activated through recognition and response toconserved pathogen associated molecular patterns (PAMPs). In addition, immunity can be induced in tissues remote from...
ORGANISM(S): Arabidopsis thaliana 
2007-01-22 | GSE6831 | GEO
UnknownRegulation of sleep plasticity by a thermo-sensitive circuit in Drosophila.
Not available
S-EPMC5233985 | biostudies-literature
UnknownParacoccidioides brasiliensis downmodulates α3 integrin levels in human lung epithelial cells in a TLR2-dependent manner.
Not available
S-EPMC7655819 | biostudies-literature
UnknownSTING and IRF3 in stromal fibroblasts enable sensing of genomic stress in cancer cells to undermine oncolytic viral therapy.
Not available
S-EPMC7611090 | biostudies-literature
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