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ProteomicsCan Scoliotic Discs be Controls for Molecular Studies in Intervertebral Disc Research?- Insights from Proteomics.
Research on disc degeneration has been heterogeneous in their use of control discs used for comparison with diseased discs. Discs from scoliosis, cadavers and voluntary organ donors are the common controls used in intervertebral disc research. In order to find out the ideal control among these discs...
ORGANISM(S): Homo sapiens (Human) 
2022-06-09 | PXD018968 | Pride
Np Esi-lc-ms/ms Human Scoliosis Ivd Control discs 
TranscriptomicsGenome-wide binding of Sd and Yki in imaginal discs
The transcription cofactor Yki drives growth and proliferation in part by controlling mitochondrial network formation. To determine if Yki and Sd are directly bound to DNA corresponding to mitochondrial genes, we used chromatin immunoprecipitation and whole genome tiling arrays (ChIP-chip) to identi...
ORGANISM(S): Drosophila melanogaster 
2012-10-03 | E-GEOD-26678 | biostudies-arrayexpress
TranscriptomicsThe exon junction complex regulates the splicing of cell polarity gene dlg1 to control Wingless signaling in development
Wingless (Wg)/Wnt signaling is conserved in all metazoan animals and plays critical roles in development. The Wg/Wnt morphogen reception is essential for signal activation, whose activity is mediated through the receptor complex and a scaffold protein Dishevelled (Dsh). We report here that the exon ...
ORGANISM(S): Drosophila melanogaster 
2016-08-19 | E-GEOD-81220 | biostudies-arrayexpress
TranscriptomicsComparison of ATAC seq between control wing imaginal discs and salm/salr knockdown wing imaginal discs
Chromatin accessibility was assayed in control of salm/salr double knockdown third instar wing imaginal discs. Imaginal discs of the stated genotypes were fixed in PFA and treated for ATAC-seq. For each genotype, two biological replicates were collected and used to construct the ATAC libraries. Libr...
ORGANISM(S): Drosophila melanogaster 
2025-05-05 | E-MTAB-14107 | biostudies-arrayexpress
TranscriptomicsExpression data from L3 Drosophila antennal-eyediscs
Growth of the drosophila eye imaginal discs is controlled by the activation of Notch in the dorsal-ventral boundary. Overexpression in the eye disc of the Notch ligand Delta together with lola and pipsqueak from the GS(2)88A8 line induces tumoral growth. We used microarray to analyze the expression ...
ORGANISM(S): Drosophila melanogaster 
2012-02-20 | E-GEOD-35471 | biostudies-arrayexpress
GenomicsComparison of ChIP of H3K27ac in control wing imaginal discs and in salm/salr knock down wing imaginal discs
H3K27ac was assayed in control of salm/salr double knockdown third instar wing imaginal discs (Drosophila melanogaster). For each genotype, two biological replicates were collected and used to construct the ChIP libraries and a matched input library (no antibody). Libraries were sequenced (paired-en...
ORGANISM(S): Drosophila melanogaster 
2025-05-05 | E-MTAB-14106 | biostudies-arrayexpress
GenomicsGenome-wide chromatin analysis of wing imaginal discs
We report the relationship between 'absent, small or homeotic discs 2' (ASH2) occupancy, histone modifications and the transcription machinery using the wing disc as a source of chromatin. Our results indicate that genes related to development and transcriptional regulation are direct targets of ASH...
ORGANISM(S): Drosophila melanogaster 
2011-02-17 | E-GEOD-24115 | biostudies-arrayexpress
TranscriptomicsGenome-wide binding of Ubx and Hth in 3rd thoracic imaginal discs
The Hox genes are responsible for generating morphological diversity along the anterior-posterior axis during animal development. The Drosophila Hox gene Ultrabithorax (Ubx), for example, is required for specifying the identity of the third thoracic (T3) segment of the adult, which includes the dors...
ORGANISM(S): Drosophila melanogaster 
2011-01-21 | E-GEOD-26793 | biostudies-arrayexpress
GenomicsComparison of ATAC seq between control wing imaginal discs and salm/salr knockdown wing imaginal discs
Comparison of ATAC seq between control wing imaginal discs and salm/salr knockdown wing imaginal discs
PRJEB75828 | ENA
TranscriptomicsTranscription profiling by array of Drosophila wild type and neoplastically transformed (lgl mutant) imaginal discs
In Drosophila, homozygosity for neoplastic tumor suppressors, like lethal giant larvae, lgl results in malignant transformation of all larval imaginal discs. To gain insight into the molecular players involved in fly tumorigenesis we undertook genome-wide transcriptional profiling of neoplastically...
ORGANISM(S): Drosophila melanogaster 
2011-09-21 | E-MEXP-2920 | biostudies-arrayexpress
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