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TranscriptomicsTranscriptional impact of organophosphate and metal mixtures on olfaction: copper dominates the chlorpyrifos-induced response in adult zebrafish.
Chemical exposures in fish have been linked to loss of olfaction leading to an inability to detect predators and prey and decreased survival. However, the mechanisms underlying olfactory neurotoxicity are not well characterized, especially in environmental exposures which involve chemical mixtures. ...
ORGANISM(S): Danio rerio 
2013-05-21 | E-GEOD-47039 | biostudies-arrayexpress
TranscriptomicsMolecular responses of human lung epithelial cells to the toxicity of copper oxide nanoparticles inferred from whole genome expression analysis.
This study proposes a molecular mechanism for lung epithelial A549 cell response to copper oxide nanoparticles (CuO-NPs) related to Cu ions released from CuO-NPs. Cells that survived exposure to CuO-NPs arrested the cell cycle as a result of the downregulation of proliferating cell nuclear antigen (...
ORGANISM(S): Homo sapiens 
2012-01-05 | E-GEOD-33278 | biostudies-arrayexpress
UnknownAβ neurotoxicity depends on interactions between copper ions, prion protein, and N-methyl-D-aspartate receptors.
Not available
S-EPMC3277185 | biostudies-literature
GenomicsRetinoid X receptors orchestrate osteoclast differentiation and postnatal bone remodeling [RXR and PPARg]
Data from nuclear receptors RXR and PPARg binding to the genome was visualized using Genome Browser (UCSC) in order to test their role in Mafb transcriptional regulation RXR and PPARg ChIP was performed in thioglycollate-elicited peritoneal macrophages in basal conditions
ORGANISM(S): Mus musculus 
2015-02-04 | E-GEOD-63696 | biostudies-arrayexpress
ProteomicsProteomic analysis of HoxB8-derived macrophages in which the Slc31a1 or Atp7a genes were inactivated using CRISPR/Cas9
This project is part of a study aimed at elucidating how Mycobacterium tuberculosis responds to physiologically relevant copper levels during macrophage infection. Here, we conducted a proteomic analysis of macrophages derived from immortalized HoxB8 hematopoietic precursors, in which the Slc31a1 (e...
ORGANISM(S): Mus musculus (Mouse) 
2026-08-25 | PXD076718 | Pride
Copper receptors Atp7a Slc31a1 Macrophages 
UnknownCopper-mediated thiol potentiation and mutagenesis-guided modeling suggest a highly conserved copper-binding motif in human OR2M3.
Not available
S-EPMC7256108 | biostudies-literature
UnknownThe Role of 20-HETE, COX, Thromboxane Receptors, and Blood Plasma Antioxidant Status in Vascular Relaxation of Copper-Nanoparticle-Fed WKY Rats.
Not available
S-EPMC8623823 | biostudies-literature
TranscriptomicsGenome-wide Binding Site Mapping of Retinoic Acid Receptors and Coregulators in Breast Cancer Cells
Retinoic acid (RA) triggers growth-suppressive effects in tumor cells and therefore RA and its synthetic analogs have great potential as anti-carcinogenic agents. RA effects are mediated by retinoic acid receptors (RARs), which regulate gene expression in an RA-dependent manner. To define the geneti...
ORGANISM(S): Homo sapiens 
2009-03-16 | E-GEOD-15244 | biostudies-arrayexpress
UnknownSoluble and membrane-bound protein carrier mediate direct copper transport to the ethylene receptor family.
Not available
S-EPMC6656775 | biostudies-literature
TranscriptomicsOrphan Nuclear Receptors expression and function in breast cancer cells: NR2F6 exerts a proliferative action
Orphan-Nuclear-Receptors (ONRs) are a group of ligand dependent transcriptional factors belonging to the family of Steroid-Nuclear-Receptors, which includes estrogen, progesterone and retinoic acid receptors. The ONR denomination refers to the fact that the endogenous ligands of these 15 nuclear re...
ORGANISM(S): Homo sapiens 
2025-04-15 | E-MTAB-14498 | biostudies-arrayexpress
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