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ProteomicsIdentification of evolutionarily conserved nuclear matrix proteins and their prokaryotic origins
Compared to prokaryotic cells, a typical eukaryotic cell is much more complex along with its endomembrane system and membrane-bound organelles. Although the endosymbiosis theories convincingly explain the evolution of membrane-bound organelles such as mitochondria and chloroplasts, very little is un...
ORGANISM(S): Danio rerio (Zebrafish) (Brachydanio rerio) Drosophila melanogaster (Fruit fly) 
2021-01-26 | PXD012926 | Pride
Core nuclear matrix proteome Nuclear evolution Nuclear matrix Nucleoskeleton Nuclear architecture 
ProteomicsExtracellular matrix proteome remodeling with substrate stiffness
Extracellular matrix proteomic profiling Mass spectrometry characterization illustrated a reprogrammed proteome in response to matrix stiffness, including a core subset of 84 ECM-specific proteins, including various ECM regulators and tissue-associated ECM-related proteins. Further, we observe remod...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
MSV000092971 | MassIVE
TranscriptomicsTissue-autonomous regulation of adipose expansion by core clock protein REVERBα
The circadian clock coordinates energy metabolism, with REVERBα considered a dominant regulator of lipid metabolism. REVERBα is a core clock protein, which demonstrates robust rhythmic expression across metabolic tissues. Here, we explore its role in white adipose metabolism, and propose that REVERB...
ORGANISM(S): Mus musculus 
2021-07-31 | E-MTAB-8840 | biostudies-arrayexpress
ProteomicsProtein composition of the extracellular matrix in idiopathic germ cell aplasia
The somatic microenvironment supports spermatogonial stem cell differentiation into sperm. Extracellular matrix (ECM) plays multiple roles in the stem cell niche, including self-renewal, proliferation, differentiation and survival of spermatogonial cells. The pathophysiology of male infertility mig...
ORGANISM(S): Homo sapiens (Human) 
2019-01-07 | PXD011817 | Pride
Extracellular matrix  male infertility  label-free quantitative proteomics 
ProteomicsChanges in the nuclear proteome of developing wheat (Triticum aestivum L.) grain
Nuclear proteins of developing wheat grains collected during the cellularization, effective grain-filling and maturation phases of development were analysed.. Nuclear proteins were extracted and separated by two-dimensional gel electrophoresis. Image analysis revealed 371 and 299 reproducible spots ...
ORGANISM(S): Triticum aestivum (Wheat) 
2015-11-20 | PXD002999 | Pride
Developing grain Nuclear proteins Wheat Lc-ms/ms 
ProteomicsC9orf72 arginine-rich dipeptide repeat proteins disrupt importin beta-mediated nuclear import
Disruption of nucleocytoplasmic transport (NCT), including mislocalization of the importin beta cargo, TDP-43, is a hallmark of amyotrophic lateral sclerosis (ALS), including ALS caused by a hexanucleotide repeat expansion in C9orf72. However, the mechanism(s) remain unclear. Importin beta and its c...
ORGANISM(S): Homo sapiens (Human) 
2020-05-20 | PXD015656 | Pride
Importin beta Nuclear transport Amyotrophic lateral sclerosis C9orf72 
ProteomicsGlobal proteomic analysis of extracellular matrix in mouse and human brain highlights association with cerebrovascular disease
The extracellular matrix (ECM), a key interface between the cerebrovasculature and other cells within the neuro-glial-vascular unit , provides structural stability and modulates cell behaviour and signalling. These functions are dependent on ECM protein composition. Since ECM defects may contribute ...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2021-03-11 | PXD020436 | Pride
Ecm Basement membrane Cerebrovascular Matrisome Proteome Extracellular matrix 
ProteomicsA snapshot of Bothrops jararaca snake venom gland subcellular proteome
The synthesis of snake venom proteins is subjected to finely regulated processes in the specialized secretory epithelium within the venom gland. Such processes occur within a defined time frame in the cell and at specific cellular locations. Thus, the determination of subcellular proteomes allows th...
ORGANISM(S): Bothrops jararaca (Jararaca) (Bothrops jajaraca) 
2023-09-30 | PXD040239 | Pride
Bothrops jararaca Snake venom Snake venom gland Proteome Subcellular fractionation 
ProteomicsEnhancer bound proteome of intronic Ig Emu CORE enhancer with reverse DNA sequence polarity control bait
The specificity of humoral immune responses depends on the functional rearrangement and expression of only one allele of immunoglobulin (Ig) genes. Here, we analyzed the comprehensive proteome of the murine Ig Emu CORE enhancer, which governs the rearrangement and expression of the Ig mu heavy chai...
ORGANISM(S): Mus musculus (Mouse) 
2024-10-25 | PXD045637 | Pride
Ap-ms Reverse chip Lc-ms Silac Dna protein interaction Immunoglobulin ig emu enhancer 
ProteomicsAcid bone lysates: what we eliminate by preparing demineralized bone matrix
Demineralized bone matrix is a widely used allograft where not only the inorganic mineral but also embedded growth factors are removed by hydrochloric acid. The cellular response to the growth factors released during the preparation of demineralized bone matrix, however, has not been studied. Here w...
ORGANISM(S): Homo sapiens (Human) Sus scrofa domesticus (domestic pig) 
2018-11-04 | PXD010145 | Pride
Growth factors Bone matrix Acid bone lysates 
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