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TranscriptomicsTranscriptomic analysis of cultured corneal endothelial cells as a validation for their use in cell-replacement therapy
The corneal endothelium plays a primary role in maintaining corneal homeostasis and clarity, and must be surgically replaced with allogenic donor corneal endothelium in the event of visually significant dysfunction. However, a worldwide shortage of donor corneal tissue has led to a search for altern...
ORGANISM(S): Homo sapiens 
2015-09-04 | E-GEOD-65991 | biostudies-arrayexpress
GenomicsA Genome-Wide Association Study of Fuchs' Endothelial Corneal Dystrophy (FECD)

Fuchs' Endothelial Corneal Dystrophy (FECD) is a common disease that results in loss of vision associated with progressive corneal edema and loss of corneal transparency. In the initial stages of the disease, excrescences on Descemet's membrane with the appearance of an abnormal posterior...

phs000421.v1.p1 | EGA
ProteomicsTranscriptome and proteome analysis of the human corneal endothelium and aqueous humor reveal endothelial cell dysfunction markers
Background: The underlying mechanism as well as diagnostic molecular biomarkers for corneal endothelial cell dysfunction (CECD) remain elusive. This study aimed to elucidate molecular mechanism of CECD via proteomic and transcriptomic approaches and identify novel biomarkers in aqueous humor (AH) di...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD023772 | Pride
Proteomics Aqueous humor Corneal endothelial cell dysfunction Transcriptomics Biomarker Bullous keratopathy 
ProteomicsProteomic analysis of Descemet's membrane with corneal endothelial cells derived from patients with Fuchs endothelial corneal dystrophy and healthy control subjects
This dataset contains proteomic profiles of Descemet's membrane (DM) with corneal endothelial cells derived from patients with Fuchs endothelial corneal dystrophy (FECD) and non-FECD subjects by shotgun proteomics. FECD is the most common inherited corneal disease. Fibrillar focal excrescences, call...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-01-17 | MSV000091078 | MassIVE
ProteomicsTCF4 trinucleotide repeat expansion drives distinct proteomic signatures in Fuchs endothelial corneal dystrophy
The aims of this study were to use an isogenic cell model system to investigate the proteomic consequences of TCF4 trinucleotide repeat expansion in Fuchs endothelial corneal dystrophy (FECD) and to identify potential molecular pathways contributing to disease pathogenesis. We used our previously es...
ORGANISM(S): Homo sapiens (Human) 
2026-06-08 | PXD075094 | Pride
Retina Fuchs endothelial corneal dystrophy (fecd) Ctg repeat 
UnknownSafety and efficacy of human ESC-derived corneal endothelial cells for corneal endothelial dysfunction.
Not available
S-EPMC10629087 | biostudies-literature
UnknownLong-Term Observation and Sequencing Analysis of SKPs-Derived Corneal Endothelial Cell-Like Cells for Treating Corneal Endothelial Dysfunction.
Not available
S-EPMC8182626 | biostudies-literature
UnknownLong-term observation after transplantation of cultured human corneal endothelial cells for corneal endothelial dysfunction.
Not available
S-EPMC9166479 | biostudies-literature
GenomicsSmall-Molecule Conversion of Neural Crest Cells to Corneal Endothelial Cells for Endothelial Regeneration
Small-Molecule Conversion of Neural Crest Cells to Corneal Endothelial Cells for Endothelial Regeneration
PRJNA1423264 | ENA
UnknownGeneration and Feasibility Assessment of a New Vehicle for Cell-Based Therapy for Treating Corneal Endothelial Dysfunction.
Not available
S-EPMC4927169 | biostudies-literature
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