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TranscriptomicsIn vivo endothelial transcriptional profiles of porcine coronary and iliac arteries
Phenotypic heterogeneity among arterial ECs is particularly relevant to atherosclerosis since the disease occurs predominantly in major arteries, which vary in their atherosusceptibility. To explore EC heterogeneity, we used DNA microarrays to compare gene expression profiles of freshly harvested po...
ORGANISM(S): Sus scrofa 
2010-06-20 | E-GEOD-10938 | biostudies-arrayexpress
TranscriptomicsComparison of young and aged F344 rat coronary artery
Previous studies showed that aging in coronary arteries is associated with pro-inflammatory phenotypic changes and decreased NO bioavailability, which, we hypothesized, promotes vascular disease by inducing endothelial apoptosis. To test this hypothesis we characterized pro-apoptotic alterations in ...
ORGANISM(S): Rattus norvegicus 
2010-06-05 | E-GEOD-619 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human coronary arteries from patients with and without collateral artery vessels to identify novel markers of coronary collateralization
Evaluation of transcriptional regulation in Coronary artery disease patients with and without collateral artery vessels.
ORGANISM(S): Homo sapiens 
2006-03-10 | E-MEXP-564 | biostudies-arrayexpress
ProteomicsECM characterization in stented porcine coronary arteries LC-MS/MS
Bare-metal (BMS) and drug-eluting stents (DES) were implanted in pig coronary arteries with an overstretch during coronary angioplasty under optical coherence tomography guidance. Arteries subjected to plain old balloon angioplasty (POBA) alone served as controls. Stented/balloon dilated segments we...
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2017-11-24 | PXD005726 | Pride
Coronary arteries Neointima Media Pig Lc-ms/ms 
TranscriptomicsGene expression patterns in peripheral blood correlate with the extent of coronary artery disease
Gene expression profile in circulating leukocytes identifies patients with coronary artery disease Peter Sinnaeve, Mark Donahue, Peter Grass, Jacky Vonderscher, David Seo, Pascal Goldschmidt, Christopher Granger Department of Medicine, Duke University, Durham, NC, USA, Novartis Institute for Biome...
ORGANISM(S): Homo sapiens 
2008-10-31 | E-GEOD-12288 | biostudies-arrayexpress
TranscriptomicsMouse, pig, and human atherosclerotic lesions have common and distinct mesenchymal cell populations
The single-cell RNA-seq experiment aims to explore the cell-type composition of right coronary artery plaques to provide an overview of human-like atherosclerosis. The PCSK9 transgenic minipigs were subjected to 15 months of HFHC diet (HFHC group f, n=4; m, n=1). At the time of euthanasia, plaque pa...
ORGANISM(S): Sus scrofa 
2025-08-30 | E-MTAB-15464 | biostudies-arrayexpress
GenomicsCirculating microRNAs in patients with aneurysmal dilatation of coronary arteries
Circulating microRNAs in patients with aneurysmal dilatation of coronary arteries
PRJNA817238 | ENA
TranscriptomicsGene expression in tissues of Mus musculus with innate immunity stimulation
This is an investigation of whole genome gene expression level in tissues of mice stimulated by LPS, FK565 or LPS + FK565 in vivo and ex vivo. We show that parenteral administration of a pure synthetic Nod1 ligand, FK565, induces site-specific vascular inflammation in mice, which is prominent in aor...
ORGANISM(S): Mus musculus 
2011-03-01 | E-GEOD-20930 | biostudies-arrayexpress
GenomicsIntegrative fine-mapping of regulatory variants and mechanisms at coronary artery disease loci
Coronary artery disease (CAD) is the leading cause of mortality and morbidity driven by both genetic and environmental risk factors. Meta-analyses of genome-wide association studies (GWAS) have identified multiple single nucleotide polymorphisms (SNPs) associated with CAD and myocardial infarction (...
ORGANISM(S): Homo sapiens 
2016-07-06 | E-GEOD-72696 | biostudies-arrayexpress
GenomicsChromatin accessibility profiling of human coronary arteries identifes disease regulatory variants
Chromatin accessibility profiling of human coronary arteries identifes disease regulatory variants
PRJNA778764 | ENA
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