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TranscriptomicsNF-kB target genes in dendritic cells
The ability of dendritic cells (DC) to initiate immunity and induce antigen-specific tolerance makes DC ideal targets for pharmacological intervention into immune responses. NF-kB factors are a family of transcriptional regulators important for DC development and function. However, the identity of N...
ORGANISM(S): Mus musculus 
2012-12-31 | E-GEOD-8009 | biostudies-arrayexpress
TranscriptomicsVitamin D3 affects TNFa mediated activation of dendritic cells
The ability of dendritic cells (DC) to initiate immunity and induce antigen-specific tolerance makes DC ideal targets for pharmacological intervention into immune responses. NF-kB factors are a family of transcriptional regulators important for DC development and function. However, the identity of N...
ORGANISM(S): Mus musculus 
2012-12-31 | E-GEOD-8334 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human fetal lung epithelial cells in undifferentiated state and after type II cell differentiation induced by DCI treatment
Studies of human fetal lung in explant culture and in isolated epithelial cells have demonstrated that both glucocorticoids and cyclic AMP promote differentiated alveolar type II cell phenotype as assessed by ultrastructural morphology and surfactant production. This project profiles changes in gen...
ORGANISM(S): Homo sapiens 
2007-11-22 | E-GEOD-3306 | biostudies-arrayexpress
TranscriptomicsAcquisition of alveolar fate and differentiation competence by human fetal lung epithelial progenitor cells
Our data show that Wnt and FGF signalling, and the downstream transcription factors NKX2.1 and TFAP2C, promote human alveolar or airway fate respectively. Moreover, we have functionally validated cell-cell interactions in human lung alveolar patterning. We show that Wnt signalling from differentiati...
ORGANISM(S): Homo sapiens 
2022-02-28 | E-MTAB-11435 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Arabidopsis mutant REVOLUTA (HDZIPIII) to identify downstream targets
The establishment of ad/abaxial polarity is a fundamental event in plant development. It is critical for correct polar development of the leaf (the upper portion of the leaf is chloroplast rich and optimized for light capture while the lower portion is optimized for gas exchange) and for creating a...
ORGANISM(S): Arabidopsis thaliana 
2008-06-15 | E-GEOD-7003 | biostudies-arrayexpress
TranscriptomicsComparison of exon profiles before and after hormone induction
Exon array analysis component. Development, differentiation, and response to environmental stimuli are characterized by sequential changes in cellular state initiated by the de novo binding of induced or temporally regulated transcriptional factors to their cognate genomic sites. The mechanism where...
ORGANISM(S): Mus musculus 
2010-12-21 | E-GEOD-26189 | biostudies-arrayexpress
TranscriptomicsExpression analysis of murine bone marrow (BMDM) derived macrophages stimulated with C1q
Investigation of whole genome gene expression level changes in BMDM adhered for 4 or 18hrs to Lab Tek Chamber slides pre-coated with 4ug/ml of human serum albumin (HSA) (control protein) or purified human C1q and treated with lipopolysaccharide (LPS: 20ng/ml) Mycobacterium avium 101 (M avium) or ap...
ORGANISM(S): Mus musculus 
2012-03-01 | E-GEOD-35280 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Arabidopsis seedlings expressing LEC2-Glucocorticoid Receptor fusion protein, induced with dexamethasone for 0, 1 or 4 hours
LEAFY COTYLEDON2 activity was induced via a LEC2-Glucocorticoid Receptor fusion protein in Arabidopsis seedlings. Experiment Overall Design: Transgenic plants carrying a 35S:LEC2-Glucocorticoid Receptor transgene were used for LEC2 induction. Activity was induced in 8 day old seedlings for 1 or 4 h...
ORGANISM(S): Arabidopsis thaliana 
2007-10-03 | E-GEOD-3959 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human samples from multiple myeloma patients treated with bortezomib or dexamethasone
The aims of this study were to assess the feasibility of prospective pharmacogenomics research in multicenter international clinical trials of bortezomib in multiple myeloma and to develop predictive classifiers of response and survival with bortezomib. Patients with relapsed myeloma enrolled in pha...
ORGANISM(S): Homo sapiens 
2008-06-17 | E-GEOD-9782 | biostudies-arrayexpress
TranscriptomicsSexual Dimorphic Regulation of Liver Gene Expression by Glucocorticoids
Males and females exhibit differences in the incidence of many major diseases including auto-immune diseases, hepatocellular carcinoma, diabetes, and osteoporosis, which all have important inflammatory components in their etiology. Glucocorticoids are the primary physiological anti-inflammatory horm...
ORGANISM(S): Rattus norvegicus 
2010-10-01 | E-GEOD-13461 | biostudies-arrayexpress
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