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TranscriptomicsSingle cell transcriptomics analysis of induced pluripotent stem cell-derived cortical neurons reveals frequent dual layer identity
Induced pluripotent stem cell (iPSC)-derived cortical neurons present a powerful new model of neurological disease. Previous work has established that differentiation protocols produce cortical neurons but little has been done to characterise these at cellular resolution. In particular, it is unclea...
ORGANISM(S): Homo sapiens 
2016-01-08 | E-GEOD-69790 | biostudies-arrayexpress
TranscriptomicsThe protomap is propagated to cortical plate neurons through an Eomes-dependent intermediate map
The cortical area map is initially patterned by transcription factor (TF) gradients in the neocortical primordium, which define a protomap in the embryonic ventricular zone (VZ). However, mechanisms that propagate regional identity from VZ progenitors to cortical plate (CP) neurons are unknown. Here...
ORGANISM(S): Mus musculus 
2013-04-02 | E-GEOD-43387 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse FACS-purified cortical projection neurons using Affymetrix 430 2.0 microarrays
3 subtypes of cortical projection neurons were purified by fluorescence-activated cell sorting (FACS) at 4 different stages of development from mouse cortex. A detailed description of the data set is described in Arlotta, P et al (2005) and Molyneaux, BJ et al (2009). The hybridization cocktails use...
ORGANISM(S): Mus musculus 
2009-10-09 | E-GEOD-17783 | biostudies-arrayexpress
TranscriptomicsUncovering the Molecular Logic of Cortical Wiring between Neuronal subtypes Across Development Through Ligand–Receptor Inference
The cerebral cortex comprises diverse excitatory and inhibitory neuron subtypes, each with distinct laminar positions and connectivity patterns. Yet, the molecular logic underlying their precise wiring remains poorly understood. To identify ligand–receptor (LR) interactions involved in cortical circ...
ORGANISM(S): Mus musculus 
2026-01-30 | E-MTAB-16260 | biostudies-arrayexpress
TranscriptomicsExpression profiles of primary cortical neurons after knocking down Fus
To clarify the functional properties of FUS, we established the differentially expressed alternative exons in FUS-silenced primary cortical neurons by using exon-sensitive microarray technology. We analyzed total RNA of primary cortical neuron infected with lentivirus expressing shRNA against mouse ...
ORGANISM(S): Mus musculus 
2012-07-23 | E-GEOD-36153 | biostudies-arrayexpress
TranscriptomicsRNA-seq of human and mouse stem-cell derived neurons and mouse primary cortical neurons after KCl-induced membrane depolarization against controls.
This experiment comprises RNA-seq data used to study evolutionary differences between humans and mice in neuronal activity-dependent transcriptional responses. Activity-dependent transcriptional responses in developing human stem cell-derived cortical neurons were compared with those induced in deve...
ORGANISM(S): Mus musculus 
2017-02-16 | E-MTAB-5489 | biostudies-arrayexpress
TranscriptomicsSingle-nucleus data for Uncovering the Molecular Logic of Cortical Wiring between Neuronal subtypes Across Development Through Ligand–Receptor Inference
The cerebral cortex comprises diverse excitatory and inhibitory neuron subtypes, each with distinct laminar positions and connectivity patterns. Yet, the molecular logic underlying their precise wiring remains poorly understood. To identify ligand–receptor (LR) interactions involved in cortical circ...
ORGANISM(S): Mus musculus 
2025-12-14 | E-MTAB-16355 | biostudies-arrayexpress
ProteomicsPhactr1/PP1 phosphatase substrates in mouse primary neurons
Neurons express Phactr1 at high level (Allen et al., 2004), and Phactr1 mutations are associated with morphological and functional developmental defects in cortical neurons (Hamada et al., 2018). To identify targets of the Phactr1/PP1 phosphatase holoenzyme, we cultured hippocampal and cortical neur...
ORGANISM(S): Mus musculus (Mouse) 
2020-10-28 | PXD019882 | Pride
Neurons Phosphatase Mouse Phactr1 
ProteomicsUbiquitinated proteome of E15.5 murine cortical neurons
TRIM9 and TRIM67 are neuronally-enriched E3 ubiquitin ligases essential for neuronal morphogenesis and responses to the axon guidance cue netrin-1. Deletion of either gene in the mouse results in subtle neuroanatomical anomalies yet overt deficits in spatial learning and memory. The identify of few ...
ORGANISM(S): Mus musculus (Mouse) 
2021-01-04 | PXD021818 | Pride
Embryonic cortical neurons Ubiquitinate proteome Orbitrap fusion lumos 
TranscriptomicsPHF6 knockdown in rat cortical neurons
E18 embryonic rat cortical neurons cultured in vitro are infected with lentivirus expressing control or PHF6shRNA-2, and harvested 5 days after infection pLL3.7 lentivirus expressing control or PHF6shRNA-2 was generated in 293T cells and concentrated using ultracentrifuge. In vitro cultured cortical...
ORGANISM(S): Rattus norvegicus 
2013-08-01 | E-GEOD-45953 | biostudies-arrayexpress
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