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ProteomicsExtrachromosomal DNA-driven oncogene dosage heterogeneity promotes rapid adaptation to therapy in MYCN-amplified cancers
Extrachromosomal DNA (ecDNA) amplification enhances intercellular oncogene dosage variability and accelerates tumor evolution by violating foundational principles of genetic inheritance through its asymmetric mitotic segregation. Spotlighting high-risk neuroblastoma we demonstrate how ecDNA amplific...
ORGANISM(S): Homo sapiens (Human) 
2025-07-05 | PXD064049 | Pride
Mycn Neuroblastoma Proteomics 
ProteomicsK27-linked ubiquitylation promotes p97 substrate processing and is essential for cell proliferation
Conjugation of ubiquitin (Ub) to numerous substrate proteins regulates virtually all cellular processes. Eight distinct ubiquitin polymer linkages specifying different functional outcomes are generated in cells. However, the roles of some atypical poly-ubiquitin topologies, in particular linkages vi...
ORGANISM(S): Homo sapiens (Human) 
2022-04-14 | PXD023579 | Pride
Ubiquitin Proteomics K27 
ProteomicsThe TRESLIN-MTBP complex couples completion of DNA replication with S/G2 transition
It has been proposed that ATR kinase senses the completion of DNA replication to initiate the S/G2 transition. In contrast to this model, we show here that the TRESLIN-MTBP complex prevents a premature entry into G2 from early S-phase independently of ATR/CHK1 kinases. TRESLIN-MTBP acts transiently ...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD035353 | Pride
Atr Dna replication Cell cycle 
ProteomicsMulti-center longitudinal quality assessment of MS-based proteomics in plasma and serum
Advancing MS-based proteomics towards clinical applications evolves around developing standardized start-to-finish and fit-for-purpose workflows for clinical specimens. Steps along the method design involve the determination and optimization of several bioanalytical parameters such as selectivity, s...
ORGANISM(S): Homo sapiens (Human) 
2025-02-14 | PXD054073 | Pride
Plasma Serum Round robin study R package mpwr Lc-ms/ms 
ProteomicsProteomics reveals NNMT as a master metabolic regulator of cancer associated fibroblasts
High-grade serous carcinoma has a poor prognosis, owing primarily to its early dissemination throughout the abdominal cavity. Genomic and proteomic approaches have provided snapshots of the proteogenomics of ovarian cancer, but a systematic examination of both the tumour and stromal compartments is ...
ORGANISM(S): Homo sapiens (Human) 
2019-04-18 | PXD006396 | Pride
Ovarian cancer proteomics laser microdissection 
UnknownOther malignancies in the history of CLL: an international multicenter study conducted by ERIC, the European Research Initiative on CLL, in HARMONY.
Not available
S-EPMC10685149 | biostudies-literature
UnknownComparison of "IN-REC-SUR-E" and LISA in preterm neonates with respiratory distress syndrome: a randomized controlled trial (IN-REC-LISA trial).
Not available
S-EPMC11218154 | biostudies-literature
UnknownThe impact of the COVID-19 pandemic on the Management of Locally Advanced Primary/Recurrent Rectal Cancer.
Not available
S-EPMC7436568 | biostudies-literature
UnknownInduction chemotherapy followed by chemoradiotherapy versus chemoradiotherapy alone as neoadjuvant treatment for locally recurrent rectal cancer: study protocol of a multicentre, open-label, parallel-arms, randomized controlled study (PelvEx II).
Not available
S-EPMC8179511 | biostudies-literature
UnknownThe empty pelvis syndrome: a core data set from the PelvEx collaborative.
Not available
S-EPMC10921833 | biostudies-literature
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