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TranscriptomicsHOXA9 transcriptomic analysis in GBM cell lines (U87MG, U251 and primary GBML18) and in immortalized human astrocytes (hTERT/E6/E7)
Assess gene expression patterns upon HOXA9 ectopic expression in U87MG GBM cell line and hTERT/E6/E7 immortalized human astrocytes, and HOXA9 silencing in U251 and GBML18 GBM cell lines. U87MG and hTERT/E6/E7 were retrovirally-infected with an MSCV control vector (MSCV-Control) or with a construct c...
ORGANISM(S): Homo sapiens 
2015-01-30 | E-GEOD-56517 | biostudies-arrayexpress
ProteomicsCharacterization of the secretome of glial cells exposed to glioblastoma secreted factors
Glioblastoma (GBM), the most malignant primary brain tumor, is characterized by widespread heterogeneity, leading to poor and unpredictable clinical outcomes. Recent studies have provided evidences that the tumor microenvironment has a critical role in regulating tumor growth by establishing a compl...
ORGANISM(S): Mus musculus (Mouse) 
2017-10-09 | PXD006007 | Pride
Glial cells  gliobastome  secretome  swath-ms 
GenomicsJ.Costello_20191016_dataset_rnaseq - samples
Description not provided
EGAD00001005435 | EGA
GenomicsInhibiton of the GABPB1L-containing GABP tetramer is sufficient to reverse replicative immortality in TERT promoter mutant glioblastoma cells.
Over 50 types of cancer acquire TERT promoter mutations. These single point mutations reactivate telomerase, allowing for indefinite maintenance of telomere length and enabling cellular immortalization. The transcription factor binding site created by the point mutations specifically recruit the ETS...
EGAS00001002582 | EGA
TranscriptomicsMelanoma-derived exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through upregulation of the MET oncoprotein.
Tumor-derived exosomes are emerging as mediators of tumorigenesis with a tissue-specific address and message. We explored the function of melanoma-derived exosomes in formation of primary tumors and metastatic progression in both murine models and patients. Whereas exosomes from highly metastatic me...
ORGANISM(S): Mus musculus 
2012-05-26 | E-GEOD-36584 | biostudies-arrayexpress
UnknownTiming of influenza epidemics and vaccines in the American tropics, 2002-2008, 2011-2014.
Not available
S-EPMC4814866 | biostudies-literature
UnknownWorldwide trends in hypertension prevalence and progress in treatment and control from 1990 to 2019: a pooled analysis of 1201 population-representative studies with 104 million participants.
Not available
S-EPMC8446938 | biostudies-literature
UnknownFluid hydration to prevent post-ERCP pancreatitis in average- to high-risk patients receiving prophylactic rectal NSAIDs (FLUYT trial): study protocol for a randomized controlled trial.
Not available
S-EPMC5879873 | biostudies-literature
UnknownHydroxychloroquine with or without Azithromycin in Mild-to-Moderate Covid-19.
Not available
S-EPMC7397242 | biostudies-literature
UnknownClinical characteristics and outcomes of hospital-manifested COVID-19 among Brazilians.
Not available
S-EPMC9941311 | biostudies-literature
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