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ProteomicsHippocampal synaptoproteomic changes of susceptibility and resilience of rats to chronic social isolation
The susceptibility to chronic social isolation (CSIS) is associated with development of major depression (MD). Recent studies relate MD with altered expression of synaptic proteins in specific brain regions, whereby some individuals exposed to the stressors are resistant to the stress. To explore th...
ORGANISM(S): Rattus norvegicus (Rat) 
2020-11-27 | PXD019790 | Pride
Synaptosomal fraction Rat Hippocampus Proteomics Lc-ms/ms 
ProteomicsFluoxetine triggers synaptic vesicle exo/endocytosis, mitochondrial energy metabolism and dynamics in hippocampus of socially isolated rats
We used comparative proteomic approach to identify proteome changes in purified synaptic terminals (synaptosomes) of rats exposed to chronic social isolation (CSIS) (6 weeks), animal model for depression, followed by chronic Fluoxetine treatment (last 3 weeks of CSIS) (therapeutic effect). Our aim w...
ORGANISM(S): Rattus norvegicus (Rat) 
2023-03-11 | PXD028816 | Pride
Proteomics Rat Lc-ms Hippocampus 
ProteomicsSocial isolation stress-resilient rats reveal energy metabolic shift in hippocampal nonsynaptic mitochondria
We investigated the relative quantification of proteins in hippocampal cytosolic and nonsynaptic mitochondrial (NSM) fractions of rats exposed to chronic social isolation (CSIS), an animal model of depression, comparing CSIS-resilient with CSIS-sensitive or control rats, via a comparative subproteom...
ORGANISM(S): Rattus norvegicus (Rat) 
2020-05-25 | PXD016966 | Pride
Resilience Hippocampus Rat Proteome Nonsynaptic mitochondria Lc-ms/ms 
ProteomicsProteomic analysis of hippocampal synaptosomes in chronically socially isolated rats: effect of antidepressant tianeptine
Dysregulation of brain synaptic proteins caused by chronic psychosocial stress has been linked with the development of major depression (MD). To gain insights into the pattern of synaptic proteome changes and different biological functions and pathways underlying MD and drug action, a comparative pr...
ORGANISM(S): Rattus norvegicus (Rat) 
2022-02-16 | PXD021920 | Pride
Rat Hippocampus Proteomics Lc-ms/ms 
ProteomicsAnalysis of the mouse hepatic peroxisome proteome – identification of novel protein constituents using a quantitative SWATH-MS approach
Several proteomics studies have been performed in the past in order to define the mammalian peroxisomal proteome. During the last decade, it has as well become evident, that a significant number of proteins is shared between several subcellular compartments and that specialized proteins subsets are ...
ORGANISM(S): Mus musculus (Mouse) 
2024-06-22 | PXD047931 | Pride
Ociad1 Organelle proteomics Peroxisomes Organelle interaction 
ProteomicsSmall molecule inhibitors of lysyl oxidases synergize with 5-azacytidine to restore erythropoiesis in myeloid neoplasms
In this study, we assessed the effects of lysyl oxidase (LOX/LOXL) inhibition on the composition of extracellular matrix (ECM) produced by in vitro expanded bone marrow derived mesenchymal stromal cells (MSCs) of n=3 patients with myelodysplastic syndromes (MDS) and myeloproliferative neoplasms (MPN...
ORGANISM(S): Homo sapiens (Human) 
2023-02-17 | PXD031217 | Pride
Msc Lc-ms Human Ecm 
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