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MetabolomicsIntegrated proteome and lipidome analyses place OCIAD1 at mitochondria-peroxisome intersection balancing lipid metabolism

OCIAD1 (Ovarian Cancer Immunoreactive Antigen Domain Containing 1) is a membrane protein largely localized to mitochondria, however, its function in health or disease is not well understood. To comprehensively characterize the molecular changes upon lack of OCIAD1, we used mass spectrometry to st...

2025-04-25 | MTBLS12329 | MetaboLights
ProteomicsMapping the interactome of OCIAD1 in human K562 cells
Immunoprecipitation of OCIAD1 followed by mass spectrometry analysis to identify binding partners in human cells. To determine the functional significance of OCIAD1 interactors, we also looked for interactions that were modulated by a loss-of-function mutant (F102A).
ORGANISM(S): Homo sapiens (Human) 
2021-05-14 | PXD025682 | Pride
Affinity purification Cytochrome c1 Ociad1 Mitochondria Complex iii Prohibitin 
ProteomicsCharacterizing the role of OCIAD1 in the proteolytic processing of holocytochrome c1 and CIII2 assembly
To characterize the nature of the cytochrome c1 (CYC1) processivity defect in native CIII2 assemblies we identified CYC1 peptides using mass spectrometry analysis of blue native (BN)-PAGE. Gel slices ranging from ~600-900kDa and containing CIII2 assemblies were excised from U2OS control cells, U2OS ...
ORGANISM(S): Homo sapiens (Human) 
2021-05-18 | PXD025576 | Pride
Cleavage Cytochrome c1 Ociad1 Mitochondria Complex iii Immp2l Processivity 
ProteomicsShotgun analysis of proteins co-immunoprecipitating with OCIAD1-FLAG
Interactome of OCIAD1-FLAG was studied. TMT-based relative quantification of protein levels was performed in eluates from mitochondria of HEK293 cells that expressed OCIAD1-FLAG vs empty vector and from mitochondria of OCIAD1-KO cells that expressed OCIAD1-FLAG vs empty vector.
ORGANISM(S): Homo sapiens (Human) 
2024-11-08 | PXD043863 | Pride
Coip Ociad1 Mitochondria Hek293 
ProteomicsMapping perturbations in the cellular proteome of OCIAD1 and OCIAD2 knockdown U2OS cells.
To gain insight into the function of both OCIAD paralogs, we used untargeted quantitative mass spectrometry to compare the whole-cell proteomes of control U2OS cells, U2OS cells with individual or double OCIAD1/OCIAD2 knockdown, and OCIAD1 knockdown cells in which OCIAD1 expression was reintroduced ...
ORGANISM(S): Homo sapiens (Human) 
2021-05-14 | PXD025573 | Pride
Ociad2 Knockdown Cytochrome c1 Ociad1 Mitochondria Complex iii 
UnknownOCIAD1 and prohibitins regulate the stability of the TIM23 protein translocase.
Not available
S-EPMC11672691 | biostudies-literature
UnknownOCIAD1 is a host mitochondrial substrate of the hepatitis C virus NS3-4A protease.
Not available
S-EPMC7375614 | biostudies-literature
UnknownOCIAD1 Controls Electron Transport Chain Complex I Activity to Regulate Energy Metabolism in Human Pluripotent Stem Cells.
Not available
S-EPMC6067085 | biostudies-literature
UnknownOCIAD1 contributes to neurodegeneration in Alzheimer's disease by inducing mitochondria dysfunction, neuronal vulnerability and synaptic damages.
Not available
S-EPMC6957876 | biostudies-literature
UnknownGenome-wide CRISPRi screening identifies OCIAD1 as a prohibitin client and regulatory determinant of mitochondrial Complex III assembly in human cells.
Not available
S-EPMC8154037 | biostudies-literature
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