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ProteomicsTargeting ERAP enhances anti-tumor immunity by disrupting the NKG2A/HLA-E inhibitory checkpoint
New targets that enhance anti-tumor immunity must be identified to improve the efficacy of cancer immunotherapy. Here we show that loss of endoplasmic reticulum aminopeptidase (ERAP) family proteins improves anti-tumor immunity and synergizes with immune checkpoint blockade. Mechanistically, we show...
ORGANISM(S): Homo sapiens (Human) 
2024-11-21 | PXD052031 | Pride
Human Hla-e Orbitrap Immunotherapy 
TranscriptomicsHost-Interferon-Stimulated Gene Response to Virus-Host Recombinant Variants of Hepatitis E Virus and Enhanced Viral Replication
The hepatitis E virus (HEV) is a leading cause of acute hepatitis worldwide. HEV infection can become chronic in immunocompromised individuals, in whom virus–host recombinant variants (VHRVs) can be detected. These variants often harbor host-derived insertions in the polyproline rich region (PPR), a...
ORGANISM(S): Homo sapiens 
2026-09-01 | E-MTAB-16873 | biostudies-arrayexpress
TranscriptomicsBlood and urine multi-omics analysis of the impact of e-vaping, smoking and cessation – from exposome to molecular responses
Cigarette smoking is a major cause of preventable morbidity and mortality. While quitting smoking is the best option, switching from cigarettes to non-combustible alternatives (NCAs) such as e-vapor products is a viable harm reduction approach for smokers who would otherwise continue to smoke. A key...
ORGANISM(S): Homo sapiens 
2024-02-22 | E-MTAB-12751 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling of E. coli K-12 and E. coli O157 (Sakai) following heat shock at 45 degree celsius
Escherichia coli O157 presents a number of specific problems in terms of food safety and public health. It has been found that E. coli O157 is more resistant to a number of the stresses encountered during food production such as heat, pH and osmotic shock. This greater resistance is thought to contr...
ORGANISM(S): Escherichia coli 
2018-03-20 | E-MTAB-5912 | biostudies-arrayexpress
TranscriptomicsBiological changes in C57BL/6 mice following 3 weeks of inhalation exposure to cigarette smoke or e-vapor aerosols
We compared early biological changes in mice after inhalation exposures to cigarette smoke or e-vapor aerosols (MarkTen® cartridge with Carrier, Test-1, or Test-2 formulations; 4% nicotine). Female C57BL/6 mice were exposed to 3R4F cigarette smoke or e-vapor aerosols by nose-only inhalation for up t...
ORGANISM(S): Mus musculus 
2021-02-28 | E-MTAB-10166 | biostudies-arrayexpress
TranscriptomicsA 7-month inhalation toxicology study in C57BL/6 mice demonstrates reduced pulmonary inflammation and emphysema following smoking cessation or switching to e-vapor products.
Cigarette smoking causes serious diseases, including lung cancer, heart disease, and emphysema. While cessation remains the most effective approach to minimize smoking-related disease, alternative non-combustible tobacco-derived nicotine containing products may reduce disease risks among those unabl...
ORGANISM(S): Mus musculus 
2021-03-18 | E-MTAB-9597 | biostudies-arrayexpress
TranscriptomicsTraDIS-Xpress to determine E. coli response to Piperacillin and Tazobactam separately and in combination
Found how E. coli responds to the commonly prescribed antibiotic-inhibitor combination piperacillin and tazobactam, separately and in combination. TraDIS-Xpress was performed following the protocol outlined by Yasir et al 2020 Genome Research. The results suggest tazobactam triggers the activity of ...
ORGANISM(S): Escherichia coli 
2023-08-31 | E-MTAB-13226 | biostudies-arrayexpress
TranscriptomicsApplication of a multi-layer systems toxicology framework for in vitro assessment of the biological effects of Classic Tobacco e-liquid and its corresponding aerosol using a novel e-cigarette device with MESH(TM) technology (mRNA data)
We previously put forward a multi-layer systems toxicology framework for in vitro assessment of e-liquids that is meant to complement the battery of classical assays for genotoxicity testing. The framework started with the first layer to screen e-liquids for their potential toxicity, followed by the...
ORGANISM(S): Homo sapiens 
2019-11-01 | E-MTAB-7911 | biostudies-arrayexpress
TranscriptomicsIdentification and validation of antisense RNAs in Escherichia coli
In this study transcriptional start sites (TSS) of E. coli were determined for several growth conditions To detect the complement of transcripts expressed from E. coli, we collected two independent biological replicates (B1 and B2 samples) from MG1655 wild type strain grown to exponential (OD 600 ~0...
ORGANISM(S): Escherichia coli str. K-12 substr. MG1655 
2014-10-18 | E-GEOD-55199 | biostudies-arrayexpress
ProteomicsOuter membrane vesicle proteome of Aggregatibacter actinomycetemcomitans serotype e strain 173
Aggregatibacter actinomycetemcomitans is an oral and systemic pathogen associated with aggressive forms of periodontitis, and with endocarditis. Outer membrane vesicles (OMVs) released by this species have been demonstrated to deliver effector proteins such as cytolethal distending toxin (CDT) and l...
ORGANISM(S): Aggregatibacter actinomycetemcomitans (Actinobacillus actinomycetemcomitans) (Haemophilus actinomycetemcomitans) 
2015-09-21 | PXD002509 | Pride
Gram negative Aggregatibacter actinomycetemcomitans Outer membrane vesicles Lc-ms/ms 
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