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MetabolomicsDefective mitochondrial COX1 translation due to loss of COX14 function triggers ROS-induced inflammation in liver
Mitochondrial oxidative phosphorylation (OXPHOS) fuels cellular ATP demands. OXPHOS defects lead to severe human disorders with unexplained tissue specific pathologies. Mitochondrial gene expression is essential for OXPHOS biogenesis since core subunits of the complexes are mitochondrial-encoded. CO...
2024-07-19 | MTBLS9823 | MetaboLights
TranscriptomicsTranscription profiling of mouse uterus from _gravidl_d18 wild type vs. Cox-1 knockout animal
Background: Preterm birth is the leading cause of all infant mortality. In 2004, 12.5% of all births were preterm. In order to understand preterm labor, we must first understand normal labor. Since many of the myometrial changes that occur during pregnancy are similar in mice and humans and mous...
ORGANISM(S): Mus musculus 
2008-06-16 | E-GEOD-8269 | biostudies-arrayexpress
ProteomicsMolecular characterization of a complex of Apoptosis Inducing Factor 1 (AIFM1) with cytochrome c oxidase of the mitochondrial respiratory chain
Combining mass spectrometry based chemical cross-linking and complexome profiling, we analyzed the interactome of heart mitochondria. We focused on complexes of oxidative phosphorylation and found that dimeric apoptosis inducing factor 1 (AIFM1) forms a defined complex with ~10% of monomeric cytochr...
ORGANISM(S): Bos taurus (Bovine) 
2021-09-09 | PXD025102 | Pride
Structural docking Cox Aifm1 Xl-ms Bovine heart mitochondria 
ProteomicsReanalysis of publicly available medium size protein complex data set with MaxLynx
Reanalysis of the publicly available medium size protein complex data set by Kokic and co-workers, Nat Commun. 2019 (PXD013947)
ORGANISM(S): Homo sapiens (Human) 
2022-01-11 | PXD030578 | Pride
Maxquant Cross-linking Maxlynx 
TranscriptomicsTranscription profiling of human colorectal adenocarcinoma patients after Celecoxib pre-treatment
Pharmacological inhibition of cyclooxygenase-2 (COX-2) is being explored as a chemotherapeutic option because COX-2 protein expression is often elevated in many cancers. Cancer cells treated with COX-2 inhibitors, such as the selective COX-2 inhibitor celecoxib, show growth inhibition and the induc...
ORGANISM(S): Homo sapiens 
2008-10-25 | E-GEOD-11237 | biostudies-arrayexpress
Transcriptomicscolonic vs bone marrow MSC
We found that mesenchymal stem cells isolated from colonic tissue express significantly increased expression of Ptgs2 or cox-2 compared to that of mesenchymal stem cells isolated from the bone marrow, one of the most common tissues from which this cell type is derived. We hypothesized that the loca...
ORGANISM(S): Mus musculus 
2009-12-02 | E-GEOD-19233 | biostudies-arrayexpress
ProteomicsSpin-driven Enantioselective Regulation of Cyclooxygenase-2 Activity for Rheumatoid Arthritis Therapy via Chiral Gold Nanohelices
Electron-spin dynamics represent an unexplored dimension in enzymatic catalysis, where most regulatory strategies focus on modulating active-site chemistry. Here, we present a spintronic approach that employs chiral gold nanohelices (CAu) as electron spin polarizers to enantiospecifically modulate c...
ORGANISM(S): Mus Musculus 
2026-04-08 | PXD076742 |
UnknownSynthesis, Spectroscopic and Biological Investigation of a New Ca(II) Complex of Meloxicam as Potential COX-2 Inhibitor.
Not available
S-EPMC8767366 | biostudies-literature
GenomicsAn Injectable Hf-Alendronate Supramolecular Condensate Enables Radioimmunotherapy for Osteosarcoma via COX-2/PGE2 Inhibition and Systemic Immune Activation
An Injectable Hf-Alendronate Supramolecular Condensate Enables Radioimmunotherapy for Osteosarcoma via COX-2/PGE2 Inhibition and Systemic Immune Activation
PRJNA1442013 | ENA
UnknownStability Analysis of the Asiatic Acid-COX-2 Complex Using 100 ns Molecular Dynamic Simulations and Its Selectivity against COX-2 as a Potential Anti-Inflammatory Candidate.
Not available
S-EPMC10180211 | biostudies-literature
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