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ProteomicsInteraction with AK2 establishes AIFM1 as organizing platform in mitochondria
Interactome of overexpressed, HA-tagged AIFM1 in HEK293T AIFM1 KO background vs control (3797, 3593), Interactome of overexpressed, HA-tagged AIFM1 variants in HEK293T AIFM1 KO background vs control (3859), Comparison of whole cell extract after gelfiltration of HEK293T AIFM1 KO cell line vs WT
ORGANISM(S): Homo sapiens (Human) 
2025-08-04 | PXD055617 | Pride
Aifm1 Ak2 Mitochondria 
ProteomicsAIFM1 KO and AIFM1del mutant HEK cell proteomics
Mitochondrial proteases regulate the dynamic properties of the organelle morphology and ensure functional plasticity at the cellular level. The metalloprotease OMA1 mediates constitutive and stress-inducible processing of its substrates in mitochondria, but the number of functionally characterized s...
ORGANISM(S): Homo sapiens (Human) 
2026-01-31 | PXD063602 | Pride
Aifm1 Mitochondrion Hek 
GenomicsA novel histone deacetylases inhibitor exerts promising anti-breast cancer activity via triggering AIFM1-dependent programmed necrosis
A novel histone deacetylases inhibitor exerts promising anti-breast cancer activity via triggering AIFM1-dependent programmed necrosis
PRJNA838191 | ENA
UnknownInteraction with AK2A links AIFM1 to cellular energy metabolism.
Not available
S-EPMC7617965 | biostudies-literature
TranscriptomicsA novel histone deacetylases inhibitor exerts promising anti-breast cancer activity via triggering AIFM1-dependent programmed necrosis
Breast cancer is one of the most lethal cancers in women, and its resistance to chemotherapy remains a challenging problem. Histone deacetylases inhibitors (HDACIs) are a promising therapeutic tool for breast cancer. Here, we screened a library of synthetic small molecules and identified a novel HDA...
ORGANISM(S): Homo sapiens 
2022-11-16 | GSE203025 | GEO
GenomicsOMA1-mediated cleavage of AIFM1 upon mitochondrial stress and suppression of cell growth through the control of OXPHOS activity
OMA1-mediated cleavage of AIFM1 upon mitochondrial stress and suppression of cell growth through the control of OXPHOS activity
PRJNA1257424 | ENA
TranscriptomicsOMA1-mediated cleavage of AIFM1 upon mitochondrial stress and suppression of cell growth through the control of OXPHOS activity
Mitochondrial proteases regulate the dynamic properties of the organelle morphology and ensure functional plasticity at the cellular level. The metalloprotease OMA1 mediates constitutive and stress-inducible processing of its substrates in mitochondria, but the number of functionally characterized s...
ORGANISM(S): Homo sapiens 
2026-01-30 | GSE296062 | GEO
UnknownExpanding the spectrum of neonatal-onset AIFM1-associated disorders.
Not available
S-EPMC10578896 | biostudies-literature
UnknownAIFM1, negatively regulated by miR-145-5p, aggravates hypoxia-induced cardiomyocyte injury.
Not available
S-EPMC9795367 | biostudies-literature
ProteomicsMolecular characterization of a complex of Apoptosis Inducing Factor 1 (AIFM1) with cytochrome c oxidase of the mitochondrial respiratory chain
Combining mass spectrometry based chemical cross-linking and complexome profiling, we analyzed the interactome of heart mitochondria. We focused on complexes of oxidative phosphorylation and found that dimeric apoptosis inducing factor 1 (AIFM1) forms a defined complex with ~10% of monomeric cytochr...
ORGANISM(S): Bos taurus (Bovine) 
2021-09-09 | PXD025102 | Pride
Structural docking Cox Aifm1 Xl-ms Bovine heart mitochondria 
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