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GenomicsMarinilabilia nitratireducens strain:AK2
Marinilabilia nitratireducens strain:AK2 Genome sequencing
PRJNA157957 | ENA
ProteomicsAK2 promotes the migration and invasion of lung adenocarcinoma by activating TGF-β/Smad pathway in vitro and in vivo
Adenylate kinase 2 (AK2) is a wide-spread and highly conserved protein kinase whose main function is to catalyze the exchange of nucleotide phosphate groups. In this study, we showed that AK2 regulated tumor cell metastasis in lung adenocarcinoma. Positive expression of AK2 is related to lung adenoc...
ORGANISM(S): Homo sapiens (Human) 
2021-09-18 | PXD028247 | Pride
Lung adenocarcinoma Emt Tgf-β Tumor metastasis Ak2 
TranscriptomicsAK2 deficiency affects human hematopoiesis
Reticular dysgenesis (RD) is a human Severe Combined Immunodeficiency mainly characterized by a profound neutropenia and lymphopenia. This pathology is due to mutations in the adenylate kinase 2 (AK2) gene, resulting in the loss of AK2 protein expression. AK2 is a mitochondrial protein, which regula...
ORGANISM(S): Homo sapiens 
2015-06-21 | E-MTAB-2680 | biostudies-arrayexpress
ProteomicsDPP8/9 processing of human AK2 unmasks an IAP binding motif
AK2 is n-terminally processed by methionine aminopeptidases, N-terminal acetylation and DDP8/9 to become an active protein which is then sorted in the mitochondrial intermembrane space. We used peptide pull-downs of free and acetylated N-terminal peptides of AK2 from the different processing steps t...
ORGANISM(S): Homo sapiens (Human) 
2025-03-13 | PXD047178 | Pride
Ddp8/9 cleavage Peptide pull-downs Mass spectrometry N-terminal processing N-terminal acetlyation 
ProteomicsAK2 promotes the migration and invasion of lung adenocarcinoma by activating TGF-β/Smad pathway in vitro and in vivo
Adenylate kinase 2 (AK2) is a wide-spread and highly conserved protein kinase whose main function is to catalyze the exchange of nucleotide phosphate groups. In this study, we showed that AK2 regulated tumor cell metastasis in lung adenocarcinoma. Positive expression of AK2 is related to lung adenoc...
ORGANISM(S): Homo Sapiens 
2021-09-09 | PXD028231 |
GenomicsBacillus thuringiensis strain:AK2.IIPR
Bacillus thuringiensis strain:AK2.IIPR Genome sequencing
PRJNA1281987 | ENA
GenomicsRNA-seq of granulocytes derived from control and AK2 depleted human HSPCs
RNA-seq of granulocytes derived from control and AK2 depleted human HSPCs
PRJNA743237 | ENA
ProteomicsPull-downs of non-crosslinked or in-cell SDA crosslinked FLAG-AK2-transfected 293 cells
Human cells were transfected with a plasmid encoding FLAG-AK2 and subsequently treated with a photoactivatable crosslinker, SDA, or left untreated. Pulldowns were performed from these cells, and the bead-bound material was digested and subjected to LC-MS DIA runs for analysis.
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD052867 | Pride
Dia Crossslinking Lc-ms Pulldowns Transfection Sda 
TranscriptomicsRNA-seq of granulocytes derived from control and AK2 depleted human HSPCs
Reticular Dysgenesis (RD) is a rare but devastating form of severe combined immunodeficiency, characterized by a maturation arrest of the myeloid and lymphoid lineages paired with sensorineural hearing loss. RD is caused by biallelic loss-of-function mutations in the mitochondrial enzyme adenylate k...
ORGANISM(S): Homo sapiens 
2021-07-06 | GSE179320 | GEO
UnknownAdenylate kinase 2 (AK2) promotes cell proliferation in insect development.
Not available
S-EPMC3583204 | biostudies-literature
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