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GenomicsUpregulation of COX4-2 via HIF-1α stabilization in COX4-1 deficiency
Upregulation of COX4-2 via HIF-1α stabilization in COX4-1 deficiency
PRJNA700878 | ENA
TranscriptomicsTranscriptome analysis of Cox4-2 knockout mice after OVA challenge
Cytochrome c oxidase (COX) is a 13-subunit enzyme that is a key complex of the oxidative phosphorylation system of the mitochondria, which generates the vast majority of the energy of the cell.COX subunit IV is the largest nuclear-encode subunit with important regulatory functions concerning energy ...
ORGANISM(S): Mus musculus 
2015-07-15 | E-GEOD-49694 | biostudies-arrayexpress
TranscriptomicsUpregulation of COX4-2 via HIF-1α stabilization in COX4-1 deficiency
Cytochrome-c-oxidase (COX) subunit 4 (COX4) plays important roles in the function, assembly and regulation of COX (mitochondrial respiratory complex 4), the terminal electron acceptor of the oxidative phosphorylation (OXPHOS) system. The principal COX4 isoform, COX4-1, is expressed in all tissues, w...
ORGANISM(S): Homo sapiens 
2021-02-21 | GSE166429 | GEO
UnknownUpregulation of COX4-2 via HIF-1α in Mitochondrial COX4-1 Deficiency.
Not available
S-EPMC7924049 | biostudies-literature
TranscriptomicsTranscriptome analysis of Cox4-2 knockout mice after OVA challenge
Cytochrome c oxidase (COX) is a 13-subunit enzyme that is a key complex of the oxidative phosphorylation system of the mitochondria, which generates the vast majority of the energy of the cell.COX subunit IV is the largest nuclear-encode subunit with important regulatory functions concerning energy ...
ORGANISM(S): Mus musculus 
2015-07-15 | GSE49694 | GEO
UnknownCytochrome C Oxidase Subunit 4 (COX4): A Potential Therapeutic Target for the Treatment of Medullary Thyroid Cancer.
Not available
S-EPMC7565757 | biostudies-literature
UnknownReplicative Stress Coincides with Impaired Nuclear DNA Damage Response in COX4-1 Deficiency.
Not available
S-EPMC9029573 | biostudies-literature
UnknownCOX4-like, a Nuclear-Encoded Mitochondrial Gene Duplicate, Is Essential for Male Fertility in Drosophila melanogaster.
Not available
S-EPMC8950493 | biostudies-literature
GenomicsMus musculus
Transcriptome analysis of Cox4-2 knockout mice after OVA challenge
PRJNA214789 | ENA
ProteomicsLoss of COX4i1 leads to combined respiratory chain deficiency and impaired mitochondrial protein synthesis
The oxidative phosphorylation (OXPHOS) system localized in the inner mitochondrial membrane secures production of the majority of ATP in mammalian organisms. Individual OXPHOS complexes form supramolecular assemblies termed supercomplexes. The complexes are linked not only by their function but also...
ORGANISM(S): Homo sapiens (Human) 
2021-02-18 | PXD023367 | Pride
Knock-out Cox Mitochondria Oxphos Complex i Cox assembly Mitochondrial protein synthesis Cox4 Biogenesis interdependency Complexome profiling 
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