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TranscriptomicsTranscription profiling of human umbilical cord blood and adult bone marrow CD34+CD33-CD38-Rho(lo)c-kit+ cells to identify candidate regulators of HSC self-renewal versus differentiation fate decisions
The global gene expression profiles of human umbilical cord blood and adult bone marrow CD34+CD33-CD38-Rho(lo)c-kit+ cells, enriched for hematopoietic stem/progenitor cells (HSC) with CD34+CD33-CD38-Rho(hi) cells, enriched in committed hematopoietic progenitor cells (HPC), were compared to identify ...
ORGANISM(S): Homo sapiens 
2007-10-30 | E-GEOD-2666 | biostudies-arrayexpress
TranscriptomicsAnalysis of extracellular matrix and adhesion molecules expression in ALL cell line
The acute lymphoblastic leukemia cells lines JM-1, REH, Nalm-27, and SUP-B15 were analyzed for baseline expression of extacellular matrix and adhesion molecules using a pathway focused cDNA microarray (SABiosciences). RNA isolated from the ALL cell lines JM-1, REH, Nalm-27, and SUP-B15 was analyzed ...
ORGANISM(S): Homo sapiens 
2010-05-01 | E-GEOD-18516 | biostudies-arrayexpress
TranscriptomicsmRNA expression profile modified by microRNA mir-517a (MIR517A) in human hepatocellular carcinoma cell line
mRNA expression profile modified by stable transfection of microRNA mir-517a (MIR517A) in a human hepatocellular carcinoma cell line Huh-7 Keywords: Hepatocellular carcinoma, Expression array, microRNA microRNA mir-517a (MIR517A) was transfected to Huh-7 cells using GFP-expressing lentiviral vector...
ORGANISM(S): Homo sapiens 
2011-02-17 | E-GEOD-20679 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of effect of chronic ethanol consumption on Rattus norvegicus pancreas
Male Wistar rats weighing 90-120 g were acclimatized for one week and fed standard laboratory chow, at which time the animals were divided into two groups. Animals were then pair-fed for 8 weeks a regular laboratory chow and water “ad libitum” or Lieber-DeCarli diet (36% calories from ethanol)....
ORGANISM(S): Rattus norvegicus 
2007-11-06 | E-GEOD-3311 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse macrophages infected with B. melitensis
Facultative intracellular Brucella infect and survive inside macrophages, and the outcome of macrophage-Brucella interaction is a basis for establishment of a chronic Brucella infection. The majority of Brucella are killed at the early infection stage. A subpopulation of virulent Brucella strains is...
ORGANISM(S): Mus musculus 
2008-06-13 | E-GEOD-5202 | biostudies-arrayexpress
TranscriptomicsUltra-deep sequencing of plasma DNA identifies druggable mutations in hepatocellular carcinoma
The purpose of the study is to detect somatic mutations in hepatocellular carcinoma using circulating free-DNA. We used deep-sequencing data of a panel of 60 commonly mutated genes in hepatocellular carcinoma.
ORGANISM(S): Homo sapiens 
2018-04-29 | E-MTAB-5123 | biostudies-arrayexpress
TranscriptomicsmicroRNA profiling of human hepatocellular carcinoma
microRNA profiling of 89 human hepatocellular carcinoma tissues using bead-based technology. microRNA expression profiling was performed using freshly frozen hepatocellular carcinoma tissues obtained at the time of surgical treatment.
ORGANISM(S): Homo sapiens 
2011-02-17 | E-GEOD-20594 | biostudies-arrayexpress
Transcriptomicsvirulence determinants of Francisella tularensis revealed by transcriptional profiling inside macrophages
The highly infectious bacterium Francisella tularensis is a facultative intracellular pathogen, whose virulence requires proliferation inside host cells, including macrophages. Although some Francisella determinants of intracellular growth have been identified, much remains to be understood about th...
ORGANISM(S): Francisella tularensis subsp. tularensis SCHU S4 
2010-05-19 | E-GEOD-12663 | biostudies-arrayexpress
TranscriptomicsNew whole blood gene expression profile predictve of preterm birth
Threatened preterm labour (TPTL) is the most common condition that requires hospitalisation during pregnancy. Most of these symptomatic women continue their pregnancies to term while only an estimated 5% will deliver a premature baby within ten days. Peripheral blood leukocytes are exposed to “activ...
ORGANISM(S): Homo sapiens 
2014-05-15 | E-GEOD-46510 | biostudies-arrayexpress
TranscriptomicsTranscriptome of the maturing erythroblast
Understanding the pattern of gene expression and identifying the specific genes expressed during erythropoiesis is crucial for a synthesis of erythroid developmental biology. Here we have isolated four distinct populations of erythroblasts at successive erythropoietin-dependent stages of erythropoie...
ORGANISM(S): Homo sapiens 
2011-03-02 | E-GEOD-22552 | biostudies-arrayexpress
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