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TranscriptomicsRNA-seq of purified T cells treated with KY1044 + anti-CD3 against anti-CD3 treated controls
KY1044 is a human monoclonal IgG1 that selectively binds to Inducible T cell CO-stimulator (ICOS). The co-stimulatory effect of KY1044-stimulated human T cells was analysed by RNA sequencing (RNA seq). Purified pre-activated (ICOS+ve) T cells were stimulated with either KY1044 and anti-CD3 or anti-C...
ORGANISM(S): Homo sapiens 
2020-09-01 | E-MTAB-9500 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse T cell sub-populations isolated from pulmonary tissue after mice were exposured to filtered air of acrolein for one week
Mice were exposed to filtered air or acrolein for 1 week. T cell subpopulations were isolated from the pulmonary tissue by cell sorting.
ORGANISM(S): Mus musculus 
2008-11-15 | E-MEXP-1354 | biostudies-arrayexpress
ProteomicsMitochondrial ATP production promotes T cell differentiation and function by regulating chromatin accessibility
Immune elimination of chronic infection or cancer requires cytotoxic CD8 T cells that adopt and maintain an effector phenotype. Cytotoxic T cell function is a bioenergetically demanding process and T cells subjected to chronic antigen exposure have compromised effector function despite high rates of...
ORGANISM(S): Mus musculus (Mouse) 
2026-10-26 | PXD066950 | Pride
T cell Ctl Dahb Cd8 
TranscriptomicsRNA sequencing of CD57+ and CD57- effector memory CD8 T cells in patients with type 1 diabetes
Type 1 diabetes is an autoimmune disease in which insulin-secreting β cells of the pancreatic islets are selectively destroyed. CD8 T cells are regarded as critical players in mediating β cell destruction and as a result, considerable effort has been expended to define CD8 T cell behaviour in this d...
ORGANISM(S): Homo sapiens 
2018-08-03 | E-MTAB-6727 | biostudies-arrayexpress
ProteomicsAMPK metabolics in T cells during GVHD
Evaluating role of AMPK in oxidative and glycolytic metabolism in T cells during graft-versus-host disease
ORGANISM(S): Mus musculus (Mouse) 
2024-10-17 | PXD052355 | Pride
Graft-versus-host Ampk 
GenomicsGenome-wide profiling of Zfp335 binding sites in thymocytes
The generation of naM-CM-/ve T lymphocytes is critical for immune function yet the mechanisms governing their maturation remain incompletely understood. We have identified a mouse mutant, bloto, that harbors a hypomorphic mutation in the zinc finger protein Zfp335. Mutant blt/blt mice exhibit a naM-...
ORGANISM(S): Mus musculus 
2014-10-17 | E-GEOD-58333 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse Th1 and Th17 T helper cells
This is to compare the gene expression profile of Th1 and Th17 cells. Experiment Overall Design: Two replicates (rep1, rep2) in two groups (Th1, Th17).
ORGANISM(S): Mus musculus 
2009-01-31 | E-GEOD-14026 | biostudies-arrayexpress
GenomicsReversible mitochondrial dysfunction drives terminal T-cell exhaustion
Reversible mitochondrial dysfunction drives terminal T-cell exhaustion
PRJNA575910 | ENA
UnknownImmunohistochemical evaluation of T cell receptor and T cell receptor beta constant 1 expression distinguishes benign and neoplastic immature T-cell populations and reveals discrete TRBC1/TCR phenotypes.
Not available
S-EPMC12701855 | biostudies-literature
UnknownAddressing the role of PKD3 in the T cell compartment with knockout mice.
Not available
S-EPMC9020081 | biostudies-literature
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