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GenomicsOpen chromatin mapping identifies transcriptional networks regulating human epididymis epithelial function [Dnase-Seq]
The epithelium lining the epididymis in the male reproductive tract maintains a luminal environment that promotes sperm cell maturation. This process is dependent on the coordinated expression of many genes that encode proteins with a role in epithelial transport. We previously generated genome-wide...
ORGANISM(S): Homo sapiens 
2015-01-07 | E-GEOD-59782 | biostudies-arrayexpress
GenomicsIndividual-specific and allele-specific chromatin signatures in diverse human populations
This dataset contains DNase-seq data and CTCF ChIP-seq data for 6 lymphoblastoid cell lines. There are 3 cell lines from a YRI trio and 3 lines from a CEU trio (HapMap GM19238, GM19239, GM 19240, GM12891, GM12892, GM12878). For data usage terms and conditions, please refer to http://www.genome.gov/...
ORGANISM(S): Homo sapiens 
2010-03-15 | E-GEOD-19622 | biostudies-arrayexpress
GenomicsHigh-resolution genome-wide in vivo footprinting of diverse transcription factors in human cells (Dnase-seq)
Using DNaseI hypersensitivity (HS) assays (Dnase-seq), high resolution DNaseI digestion profiles were generated genome-wide in diverse human cell types. We showed that within general regions of DNaseI HS that are known to identify locations of gene regulatory elements, DNaseI digestion patterns all...
ORGANISM(S): Homo sapiens 
2010-11-18 | E-GEOD-25344 | biostudies-arrayexpress
GenomicsOpen chromatin defined by DNaseI and FAIRE identifies regulatory elements that shape cell-type identity [DNase_seq].
The human body contains thousands of unique cell types, each with specialized functions. Cell identity is governed in large part by gene transcription programs, which are determined by regulatory elements encoded in DNA. To identify regulatory elements active in seven cell lines representative of di...
ORGANISM(S): Homo sapiens 
2011-06-29 | E-GEOD-30224 | biostudies-arrayexpress
GenomicsDifferential contribution of cis-regulatory elements to higher order chromatin structure and expression of the CFTR locus
Higher order chromatin structure establishes domains that organize the genome and coordinate gene expression. However, the molecular mechanisms controlling transcription of individual loci within a topological domain (TAD) are not fully understood. The cystic fibrosis transmembrane conductance reg...
ORGANISM(S): Homo sapiens 
2016-01-07 | E-GEOD-74709 | biostudies-arrayexpress
TranscriptomicsReplacing skeletal muscle alpha-actin with cardiac actin in mouse skeletal muscle
Skeletal muscle actin mice (Crawford et al., (2002) Mol Cell Biol 22, 5587) were crossed with cardiac actin transgenic mice (termed "ACTC^Coco" or "Coco" for short), to produce mice that had cardiac actin instead of skeletal muscle actin in their skeletal muscles (termed "AC...
ORGANISM(S): Mus musculus 
2009-05-24 | E-GEOD-12882 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of heart from torpid and normothermic male Siberian hamsters compared at five different time-points
Heart cDNA from torpid and normothermic male hamsters is compared at five different time-points every three hours, starting from 2h prior to lights on and finishing 10h after lights on.
ORGANISM(S): Phodopus sungorus 
2007-12-05 | E-MEXP-1185 | biostudies-arrayexpress
TranscriptomicsOpen chromatin mapping identifies transcriptional networks regulating human epididymis epithelial function
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2015-01-07 | E-GEOD-59783 | biostudies-arrayexpress
TranscriptomicsTechnical Analysis of Fundulus heteroclitus cDNA Microarrays, experiment B
Analysis of the relationship between the amount of mRNA and the fluorescent signal from the microarray hybridizations. In addition, we measured expression for differences in RNA labeling and for the day on which RNA is prepared. Keywords: Gene expression Two-condition experiment, number of rounds o...
ORGANISM(S): Fundulus heteroclitus 
2010-05-15 | E-GEOD-12898 | biostudies-arrayexpress
TranscriptomicsGene expression data from medulloblastoma tumor samples
Smoothened (SMO)-inhibitors recently entered clinical trials for sonic-hedgehog driven medulloblastoma (SHH-MB). Clinical response appears highly variable. To understand the mechanism(s) of primary resistance and to identify pathways co-operating with aberrant SHH-signaling, we sequenced a large coh...
ORGANISM(S): Homo sapiens 
2014-06-02 | E-GEOD-49243 | biostudies-arrayexpress
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