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TranscriptomicsExpression and Prognostic impact of LncRNAs in AML
Long noncoding RNAs (lncRNAs) are transcripts longer than 200 nucleotides located within the intergenic stretches or overlapping antisense transcripts of protein coding genes. LncRNAs are involved in numerous biological roles including imprinting, epigenetic regulation, apoptosis and cell-cycle. To ...
ORGANISM(S): Homo sapiens 
2014-11-26 | E-GEOD-63614 | biostudies-arrayexpress
TranscriptomicsDownregulation of microRNA expression in the lungs of rats exposed to cigarette smoke
While microRNAs have extensively been investigated in cancer research, little is known regarding their response to noxious agents in apparently healthy tissues. We analyzed the expression of 484 miRNAs in the lung of rats exposed to environmental cigarette smoke (ECS) for 28 days. ECS downregulat...
ORGANISM(S): Rattus sp. 
2010-05-19 | E-GEOD-13260 | biostudies-arrayexpress
TranscriptomicsmicroRNA expression in rat lung receiving chemopreventive agents and attenuation of cigarette smoke-induced alterations
We previously showed that exposure of rats to environmental cigarette smoke (ECS) causes extensive downregulation of microRNA expression in the lung, resulting in overexpression of multiple genes and proteins. In the present study, we evaluated by microarray the expression of 484 microRNAs in the l...
ORGANISM(S): Rattus norvegicus 
2010-05-16 | E-GEOD-19540 | biostudies-arrayexpress
TranscriptomicsMicroRNA expression profiling of male breast cancer
To test the hypothesis that there is a specific miRNA expression signature which characterizes male breast cancers, we performed miRNA microarray analysis in a series of male breast cancers and compared them to cases of male gynecomastia and female breast cancers miRNA microarray analysis was perfor...
ORGANISM(S): Homo sapiens 
2010-05-16 | E-GEOD-17155 | biostudies-arrayexpress
TranscriptomicsCXCR4/YinYang1/Hsa-let-7a axis functions as tumor suppressor in acute myeloid leukemia
Surface expression of C-X-C chemokine receptor type 4 (CXCR4) in acute myeloid leukemia (AML) has been reported to be an independent prognostic factor for disease relapse and survival. We previously reported that targeting the stromal-derived factor 1M-NM-1 (SDF-1M-NM-1)/CXCR4 axis could overcome re...
ORGANISM(S): Homo sapiens 
2013-12-01 | E-GEOD-44828 | biostudies-arrayexpress
TranscriptomicsGamma-irradiation induced T-cell lymphomas (miRNA study)
This set of data contains the expression levels of cDNAs in T-cell lymphoblastic lymphomas induced by gamma-irradiation. These tumor samples were compared to normal thymuses Keywords: Tumor profiles, comparison of tumoral versus wild-type tissues, lymphomas and leukemias C57BL/6J animals were mainta...
ORGANISM(S): Mus musculus 
2010-05-26 | E-GEOD-10891 | biostudies-arrayexpress
TranscriptomicsMiR-21 is an EGFR-regulated anti-apoptotic factor in lung cancer from never-smokers
Approximately 15% of lung cancer cases are not associated with smoking and show molecular and clinical characteristics distinct from those in smokers. Epidermal growth factor receptor (EGFR) gene mutations, which are correlated with sensitivity to EGFR-tyrosine kinase inhibitors (EGFR-TKIs), are mo...
ORGANISM(S): Homo sapiens 
2010-05-15 | E-GEOD-14936 | biostudies-arrayexpress
TranscriptomicsPaired non-cancerous and cancerous miRNA expression of esophageal adenocarcinoma and squamous cell carcinoma patients
Identifying biomarkers predictive for early esophageal cancer detection is critical considering the dismal survival rates. We investigated the involvement of microRNAs (miRNAs), their utility as biomarkers, and their association with survival in esophageal cancer, including Barrett’s associated and...
ORGANISM(S): Homo sapiens 
2010-07-09 | E-GEOD-13937 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human breast cancer cell lines and tissue samples to identify aberrant microRNA expression
MicroRNAs are a class of small non-coding RNAs that control gene expression by targeting messenger RNAs and triggering either translation repression or RNA degradation. Their aberrant expression may be involved in human diseases, including cancer. Indeed, microRNA aberrant expression has been previo...
ORGANISM(S): Homo sapiens 
2006-01-01 | E-TABM-23 | biostudies-arrayexpress
TranscriptomicsImplications of the miR-10 family in chemotherapy response of NPM1 mutated AML
Nucleophosmin mutated AML (NPM1mut-AML) patients have a high rate of complete remission (CR) to induction chemotherapy. However, the mechanisms responsible for such effects are unknown. Since miR-10 family members are expressed at high levels in NPM1mut-AML, we evaluated whether these microRNAs coul...
ORGANISM(S): Homo sapiens 
2014-05-01 | E-GEOD-55519 | biostudies-arrayexpress
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