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TranscriptomicsIncreased antigen cross-presentation but impaired cross-priming after activation of PPARγ
Increased antigen cross-presentation but impaired cross-priming after activation of PPARγ is mediated by up-regulation of B7H1 Dendritic cells (DCs) are able to take up exogenous antigens and present antigen-derived peptides on MHC class I molecules, a process termed cross-presentation. The mannose...
ORGANISM(S): Mus musculus 
2010-05-08 | E-GEOD-15616 | biostudies-arrayexpress
ProteomicsTumor-derived CDC37 inhibits antigen cross-presentation in dendritic cells and impairs anti-tumor immunity in breast cancer
Tumor mutational burden (TMB), usually representing high immunogenicity, could not always predict treatment response of immune checkpoint blockade (ICB). Here, we showed that defective antigen cross-presentation in type 1 conventional dendritic cells (cDC1) was responsible for lacking tumor-specific...
ORGANISM(S): Homo Sapiens 
2025-10-17 | PXD069576 |
ProteomicsProteomic analysis of regulated dendritic cell endosomes reveals dynamic adaptation to antigen uptake and cross-presentation
MHC class I cross-presentation involves final proteolytic peptide processing by the endosomal insulin-regulated aminopeptidase (IRAP). Reasoning that analysis of the IRAP proximal proteome may inform about dynamic remodeling of a key cross-presentation compartment during antigen uptake, we developed...
ORGANISM(S): Mus musculus (Mouse) 
2026-02-09 | PXD067092 | Pride
Endosome Insulin-regulated aminopeptidase Proximity biotinylation Cross-presentation Dendritic cell 
ModelsWodarz2003 - Cytotoxic T lymphocyte cross-priming
This a model from the article: A dynamical perspective of CTL cross-priming and regulation: implications for cancer immunology. Wodarz D, Jansen VA. Immunol Lett 2003 May 1;86(3):213-27 12706524 , Abstract: ...
2024-09-02 | BIOMD0000000685 | BioModels
GenomicsDNGR-1 signalling limits dendritic cell activation for optimal antigen cross-presentation
DNGR-1 signalling limits dendritic cell activation for optimal antigen cross-presentation
PRJNA1211014 | ENA
GenomicsAntigen cross-presentation at single-cell resolution
Antigen cross-presentation at single-cell resolution
PRJNA1237285 | ENA
TranscriptomicsIncreased antigen cross-presentation but impaired cross-priming after activation of PPARγ
Increased antigen cross-presentation but impaired cross-priming after activation of PPARγ is mediated by up-regulation of B7H1 Dendritic cells (DCs) are able to take up exogenous antigens and present antigen-derived peptides on MHC class I molecules, a process termed cross-presentation. The mannose ...
ORGANISM(S): Mus musculus 
2009-06-19 | GSE15616 | GEO
GenomicsCross-presentation by dendritic cells is limited by non-canonical autophagy.
Cross-presentation by dendritic cells is limited by non-canonical autophagy.
PRJNA553189 | ENA
TranscriptomicsImproved Innate and Adaptive Immunostimulation by Genetically Modified HIV-1 Protein Expressing NYVAC Vectors
Attenuated poxviruses are safe and capable to express foreign antigens. Poxviruses are applied in veterinary vaccination and explored as candidate vaccines for humans. However, poxviruses express multiple genes encoding proteins that interfere with components of the innate and adaptive immune respon...
ORGANISM(S): Homo sapiens 
2010-12-21 | E-GEOD-26239 | biostudies-arrayexpress
ProteomicsEnhanced antigen cross-presentation in human colorectal cancer-associated fibroblasts through upregulation of the lysosomal protease Cathepsin S
Cross-presentation of exogenous antigens in HLA-class I molecules by professional antigen presenting cells (APCs) is crucial for CD8+ T cell function. Recent murine studies show that several non-professional APCs, including cancer-associated fibroblasts (CAFs) also possess this capacity. It is curre...
ORGANISM(S): Homo sapiens (Human) 
2022-03-03 | PXD029507 | Pride
Tumor immunology Non-professional antigen presentation Parallel reaction monitoring Stromal immunobiology 
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