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ProteomicsPhosphoproteomic Analysis of Lethal Castration Resistant Prostate Cancer Reveals Patient but not Metastatic Site Heterogeneity of Tyrosine Kinase Activation
Tissue lysis was performed as previously described (Drake, J.M., et al. Oncogene-specific activation of tyrosine kinase networks during prostate cancer progression. Proc Natl Acad Sci U S A 109, 1643-1648 (2012)) Briefly, greater than 300 mg of frozen tumor mass was homogenized and sonicated in urea...
ORGANISM(S): Homo sapiens (Human) 
2013-11-21 | PXD000238 | Pride
Tyrosine phosphorylation Human Prostate cancer 
ProteomicsStructure of herpes simplex virus pUL7:pUL51, a conserved complex required for efficient herpesvirus assembly
Herpesviruses are an ancient family of highly-prevalent human and animal pathogens that acquire their membrane envelopes in the cytoplasm of infected cells. While multiple conserved viral proteins are known to be required for efficient herpesvirus production, many of these proteins lack...
ORGANISM(S): Bacteria Human alphaherpesvirus 1 Human herpesvirus 1 (strain KOS) (HHV-1) (Human herpes simplex virus 1) 
2020-05-11 | PXD015941 | Pride
Secondary envelopment  virus budding  focal adhesions  human cytomegalovirus (hcmv) 
ProteomicsWhole Cell Proteomics of HSV-1 infected i3Neurones with proteolysis inhibition
Herpes simplex virus 1 (HSV‑1) infections of the central nervous system cause encephalitis and are associated with increased risk of neurodegeneration, yet the molecular consequences of lytic infection in human neurones remain incompletely defined. We mapped the proteomic changes induced by HSV‑1 ac...
ORGANISM(S): Homo sapiens (Human) Human alphaherpesvirus 1 
2026-10-16 | PXD081186 | Pride
Human Lc-msms Bafilomycin a1 Hsv-1 Neurone Herpes simplex virus 1 Mg132 
UnknownHerpes simplex virus 1 protein pUL21 alters ceramide metabolism by activating the interorganelle transport protein CERT.
Not available
S-EPMC9668737 | biostudies-literature
UnknownFunctional divergence of a bacterial enzyme promotes healthy or acneic skin.
Not available
S-EPMC10697930 | biostudies-literature
ProteomicsWhole-cell and plasma membrane proteomics of herpes simplex virus-1 infection reveals cell surface remodelling via pUL56-mediated GOPC degradation
Herpesviruses are ubiquitous in the human population and they extensively remodel the cellular environment during infection. Multiplexed quantitative proteomic analysis over the time-course of herpes simplex virus (HSV)-1 infection was used to characterize changes in the host-cell proteome and the k...
ORGANISM(S): Homo sapiens (Human) Human alphaherpesvirus 1 
2020-10-15 | PXD021351 | Pride
Quantitative proteomics Uncharacterized orf Immune evasion Membrane trafficking Virus host interaction Proteasomal degradation Herpesvirus 
ProteomicsTemporal proteomic analysis of BK polyomavirus infection reveals virus-induced G2 arrest and highly effective evasion of innate immune sensing
BK polyomavirus (BKPyV) is a small DNA virus that establishes a life-long persistent infection in the urinary tract of most people. BKPyV is known to cause severe morbidity in renal transplant recipients and can lead to graft rejection. The simple 5.2 kilobase pair dsDNA genome expresses just seven ...
ORGANISM(S): Homo sapiens (Human) BK polyomavirus MM 
2019-05-23 | PXD013940 | Pride
Quantitative proteomics  tandem mass tag  systems virology  polyomavirus  interferon  immune evasion  innate immunity  cell cycle 
ProteomicsEZH2 inhibition overcomes immunomodulatory drug (IMiD) resistance in multiple myeloma cell lines in a CRBN pathway dependent manner
Immunomodulatory agents (IMiDs) and the next-generation Cereblon (CRBN) E3 ligase modulators (CeLMoDs), targeting the Ikaros/Aiolos-IRF4-MYC axis, are effective therapies for multiple myeloma (MM) across all stages of disease. Resistance to treatment can be acquired following exposure, but a subset ...
ORGANISM(S): Homo sapiens (Human) 
2026-03-19 | PXD057933 | Pride
Ezh2 inhibition Myeloma Imid Crbn pathway 
UnknownMycobacterium tuberculosis bloodstream infection prevalence, diagnosis, and mortality risk in seriously ill adults with HIV: a systematic review and meta-analysis of individual patient data.
Not available
S-EPMC7254058 | biostudies-literature
ProteomicsPlasma Membrane Profiling of HSV-1 infected i3Neurones
Herpes simplex virus (HSV)-1 invasion of the CNS can cause life-threatening herpes simplex encephalitis, the most common infectious encephalitis worldwide. The molecular consequences of lytic infection in CNS neurones are poorly understood, and many viral proteins remain functionally uncharacterised...
ORGANISM(S): Homo sapiens (Human) 
2026-10-16 | PXD076394 | Pride
Human Neuron Hsv-1 
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