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TranscriptomicsGenome-wide probing of RNA structure reveals active unfolding of mRNA structures in vivo
We present an approach for globally monitoring RNA structure in native conditions in vivo with single nucleotide precision. This method is based on in vivo modification with dimethyl sulfate (DMS), which reacts with unpaired adenine and cytosine residues9, followed by deep sequencing to monitor modi...
ORGANISM(S): Homo sapiens 
2013-12-15 | E-GEOD-45803 | biostudies-arrayexpress
TranscriptomicsThe structure of human Argonaute-2 in complex with miR-20a
Argonaute proteins lie at the heart of the RNA-Induced Silencing Complex (RISC), wherein they use small RNA guides to recognize targets. Some Argonaute proteins can directly cleave their targets, whereas others recruit co-factors to repress independently of “slicing.” Prior studies established the a...
ORGANISM(S): Spodoptera frugiperda 
2012-05-12 | E-GEOD-37931 | biostudies-arrayexpress
ProteomicsAn Evaluation of the Crystal Structure of C-terminal Truncated Apolipoprotein A-I in Solution Reveals Structural Dynamics Related to Lipid Binding
Apolipoprotein (apo)A-I mediates many of the anti-atherogenic functions attributed to high density lipoprotein (HDL). Unfortunately, efforts toward a high-resolution structure of full-length apoA-I have not been fruitful, though there have been successes with deletion mutants. Recently, a C-terminal...
ORGANISM(S): Homo sapiens (Human) 
2017-05-30 | PXD006574 | Pride
Apolipoprotein Mass spectrometry (ms) Structural biology Oligomerization Small-angle x-ray scattering (saxs) Structural model 
TranscriptomicsSmall RNAs generated in vitro by budding-yeast Dicer
The Dicer ribonuclease III (RNase III) enzymes process long double-stranded RNA (dsRNA) into the small interfering RNAs (siRNAs) that direct RNA interference. Here, we describe the structure and activity of a catalytically active fragment of Kluyveromyces polysporus Dcr1, which represents the noncan...
ORGANISM(S): Vanderwaltozyma polyspora 
2011-05-11 | E-GEOD-29168 | biostudies-arrayexpress
GenomicsStructure study of MarR family protein from Paenisporosarcina sp.TG-14
Crystal structure of MarR family protein from Paenisporosarcina sp. TG-14
PRJEB42800 | ENA
ProteomicsDevelopment and crystal structures of a more potent second-generation dual degrader of BCL-2 and BCL-xL
Overexpression of BCL-xL and BCL-2 play key roles in tumorigenesis and cancer drug resistance. Advances in PROTAC technology facilitated recent development of the first BCL-xL/BCL-2 dual degrader, 753b, a VHL-based degrader with improved potency and reduced toxicity compared to previous small molec...
ORGANISM(S): Homo sapiens (Human) 
2024-03-12 | PXD049976 | Pride
Protac Crystal structure Ubiquitin Ternary complex Degrader E3 ligase Bcl-xl/bcl-2 
TranscriptomicsStudy of transcriptional effects of monosodium urate crystal (MSU) on HaCaT keratinocyte cell line.
Aim of the study was to characterize at a molecular level (changes in transcriptomes) the effect of monosodium urate crystal (MSU) on HaCaT keratinocyte cell line. This was adressed by using a culture model. The HaCaT cell line (human keratinocytes) was stimulated by MSU (1mg/mL) vs control for 12 h...
ORGANISM(S): Homo sapiens 
2015-10-29 | E-GEOD-65931 | biostudies-arrayexpress
ProteomicsRevisiting high resolution crystal structure of Phormidium rubidum phycocyanin using X-ray and mass spectrometry
X-ray crystolography structure deconvolution in combination with mass spectrometry sequencing
ORGANISM(S): Phormidium rubidum A09DM 
2021-09-09 | PXD017229 | Pride
Phormidium_pc sequence 
UnknownCrystal Structure and Twisted Aggregates of Oxcarbazepine Form III.
Not available
S-EPMC9337787 | biostudies-literature
UnknownCrystal structure of Ba5In4Sb6.
Not available
S-EPMC4420070 | biostudies-literature
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