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ProteomicsChemical genetic validation of CSNK2 substrates using an inhibitor-resistant mutant in combination with triple SILAC quantitative phosphoproteomics
Casein Kinase 2 (CSNK2) is an extremely pleiotropic, ubiquitously expressed protein kinase involved in the regulation of numerous key biological processes. Mapping the CSNK2-dependent phosphoproteome is necessary for better characterization of its fundamental role in cellular signalling. While ATP-c...
ORGANISM(S): Homo sapiens (Human) 
2022-07-14 | PXD033523 | Pride
Protein kinase ck2 U2os cells Csnk2 Silac Cx-4945 Phosphoproteomics Lc-ms/ms 
UnknownCSNK2 in cancer: pathophysiology and translational applications.
Not available
S-EPMC8980014 | biostudies-literature
UnknownStrategic Fluorination to Achieve a Potent, Selective, Metabolically Stable, and Orally Bioavailable Inhibitor of CSNK2.
Not available
S-EPMC11397024 | biostudies-literature
ProteomicsComparison of CX-4945 and SCG-CK2-1 as Inhibitors of CSNK2 using Quantitative Phosphoproteomics: Triple SILAC in combination with Inhibitor-Resistant CSNK2
Specificity is a limiting factor when using small-molecule inhibitors to study protein kinase signalling. Since inhibitor-resistant kinase mutants (i.e., drug-resistant alleles) remain active in the presence of inhibitor, they facilitate validation of on-target effects. By combining an inhibitor-res...
ORGANISM(S): Homo sapiens (Human) 
2023-08-14 | PXD038050 | Pride
Protein kinase ck2 Sgc-ck2-1 U2os cells Csnk2 Silac Cx-4945 Phosphoproteomics Lc-ms/ms 
UnknownIn mammalian skeletal muscle, phosphorylation of TOMM22 by protein kinase CSNK2/CK2 controls mitophagy.
Not available
S-EPMC5902202 | biostudies-literature
UnknownFunction of CSNK2/CK2 selectively affects the endoplasmic reticulum and the Golgi apparatus in mtor-mediated autophagy induction.
Not available
S-EPMC11760280 | biostudies-literature
UnknownChemical Genetic Validation of CSNK2 Substrates Using an Inhibitor-Resistant Mutant in Combination with Triple SILAC Quantitative Phosphoproteomics.
Not available
S-EPMC9225150 | biostudies-literature
UnknownHost Kinase CSNK2 is a Target for Inhibition of Pathogenic SARS-like β-Coronaviruses.
Not available
S-EPMC9236220 | biostudies-literature
UnknownHost kinase CSNK2 is a target for inhibition of pathogenic β-coronaviruses including SARS-CoV-2.
Not available
S-EPMC8750650 | biostudies-literature
UnknownMore than an Amide Bioisostere: Discovery of 1,2,4-Triazole-containing Pyrazolo[1,5-<i>a</i>]pyrimidine Host CSNK2 Inhibitors for Combatting β-Coronavirus Replication.
Not available
S-EPMC11284802 | biostudies-literature
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