Sort   by:  
 Page size 
ProteomicsComparison of CX-4945 and SCG-CK2-1 as Inhibitors of CSNK2 using Quantitative Phosphoproteomics: Triple SILAC in combination with Inhibitor-Resistant CSNK2
Specificity is a limiting factor when using small-molecule inhibitors to study protein kinase signalling. Since inhibitor-resistant kinase mutants (i.e., drug-resistant alleles) remain active in the presence of inhibitor, they facilitate validation of on-target effects. By combining an inhibitor-res...
ORGANISM(S): Homo sapiens (Human) 
2023-08-14 | PXD038050 | Pride
Protein kinase ck2 Sgc-ck2-1 U2os cells Csnk2 Silac Cx-4945 Phosphoproteomics Lc-ms/ms 
ProteomicsFunction of CK2 selectively affects the endoplasmic reticulum and the Golgi apparatus in mTOR-mediated autophagy induction.
Selective autophagy of the endoplasmic reticulum, known as ER-phagy, is essential to maintain ER homeostasis. We recently showed that members of the autophagy receptor family FAM134 are regulated by phosphorylation-dependent ubiquitination. In an unbiased screen we had identified several kinases dow...
ORGANISM(S): Homo sapiens (Human) 
2025-03-07 | PXD049341 | Pride
Human Multiplexed Lc-ms Tmtpro 18plex Gprc Compounds 
UnknownDevelopment of a potent and selective chemical probe for the pleiotropic kinase CK2.
Not available
S-EPMC8864761 | biostudies-literature
UnknownEvaluation of a Selective Chemical Probe Validates That CK2 Mediates Neuroinflammation in a Human Induced Pluripotent Stem Cell-Derived Microglial Model.
Not available
S-EPMC9239073 | biostudies-literature
UnknownCancer selective cell death induction by a bivalent CK2 inhibitor targeting the ATP site and the allosteric αD pocket.
Not available
S-EPMC10838953 | biostudies-literature
ProteomicsFunction of ERphagy receptors is regulated via phosphorylation-dependent ubiquitination pathways
Selective autophagy of the ER (ERphagy) is an important regulator of ER remodeling and critical to maintain cellular homeostasis upon environmental changes. ERphagy receptors link the ER with autophagic membrane thus regulating ERphagy flux. We recently showed that members of the FAM134 family play ...
ORGANISM(S): Homo sapiens (Human) 
2022-08-17 | PXD036103 | Pride
Ck2 Er homeostasis Lysosomal degradation Er remodeling Er fragmentation Chek1 Atr Selective autophagy Atm Stress response Ubiquitination Fam134b Fam134c Endoplasmic reticulum Mtor 
ProteomicsThe function of ER-phagy receptors is regulated through phosphorylation-dependent ubiquitination pathways.
Selective autophagy of the endoplasmic reticulum (ER), known as ER-phagy, is an important regulator of ER remodeling and is critical to maintaining cellular homeostasis during environmental changes. We recently showed that members of the FAM134 family play a role during stress-induced ER-phagy. How...
ORGANISM(S): Homo sapiens (Human) 
2023-11-16 | PXD043003 | Pride
Ck2 Er homeostasis Lysosomal degradation Er remodeling Er fragmentation Chek1 Atr Selective autophagy Atm Ubiquitination. Stress response Fam134b Fam134c Endoplasmic reticulum Mtor 
UnknownFunction of CSNK2/CK2 selectively affects the endoplasmic reticulum and the Golgi apparatus in mtor-mediated autophagy induction.
Not available
S-EPMC11760280 | biostudies-literature
UnknownDiscovery of a Potent and Selective Naphthyridine-Based Chemical Probe for Casein Kinase 2.
Not available
S-EPMC10108397 | biostudies-literature
UnknownInhibition of CK2 Reduces NG2 Expression in Juvenile Angiofibroma.
Not available
S-EPMC9138789 | biostudies-literature
Sort   by:  
 Page size