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TranscriptomicsRNA-seq of mouse 3T3-L1 cell line treated with CX-4945 compared to untreated controls during differentiation
Pharmacological inhibition of protein kinase CK2 with CX-4945 during adipogenesis, compared to normal adipogenesis in the mouse 3T3-L1 cell line, to identify CK2-mediated biological mechanisms relevant for adipogenesis and lipogenesis.
ORGANISM(S): Mus musculus 
2025-03-17 | E-MTAB-14414 | biostudies-arrayexpress
ProteomicsComparison of CX-4945 and SCG-CK2-1 as Inhibitors of CSNK2 using Quantitative Phosphoproteomics: Triple SILAC in combination with Inhibitor-Resistant CSNK2
Specificity is a limiting factor when using small-molecule inhibitors to study protein kinase signalling. Since inhibitor-resistant kinase mutants (i.e., drug-resistant alleles) remain active in the presence of inhibitor, they facilitate validation of on-target effects. By combining an inhibitor-res...
ORGANISM(S): Homo sapiens (Human) 
2023-08-14 | PXD038050 | Pride
Protein kinase ck2 Sgc-ck2-1 U2os cells Csnk2 Silac Cx-4945 Phosphoproteomics Lc-ms/ms 
TranscriptomicsCooperative blockade of CK2 and ATM kinases drives apoptosis in VHL-deficient renal carcinoma cells / RNA-seq (BRB-seq) of treated 786-O spheroids
Multicellular Tumor Spheroids (MCTS) were pre-formed for 3 days with 786-O cell line to better mimic the tumor microenviroenment. These spheroids were treated with either vehicle (DMSO), drugs alone (KU-60019 10 μM; CX-4945 5 μM) or in combination (KU + CX) for 48h before RNA extraction.
ORGANISM(S): Homo sapiens 
2021-02-04 | E-MTAB-9977 | biostudies-arrayexpress
GenomicsTranscriptome profiling of H295R adrenocortical carcinoma cells treated with the CK2/CLK inhibitor CX-4945 (silmitasertib)
Transcriptome profiling of H295R adrenocortical carcinoma cells treated with the CK2/CLK inhibitor CX-4945 (silmitasertib)
PRJNA550353 | ENA
UnknownStructural Basis for the Selective Inhibition of Cdc2-Like Kinases by CX-4945.
Not available
S-EPMC6720368 | biostudies-literature
GenomicsRNA-seq of mouse 3T3-L1 cell line treated with CX-4945 compared to untreated controls during differentiation
RNA-seq of mouse 3T3-L1 cell line treated with CX-4945 compared to untreated controls during differentiation
PRJEB79718 | ENA
UnknownCX-4945 Induces Methuosis in Cholangiocarcinoma Cell Lines by a CK2-Independent Mechanism.
Not available
S-EPMC6162756 | biostudies-literature
UnknownIdentification of a novel function of CX-4945 as a splicing regulator.
Not available
S-EPMC3990583 | biostudies-literature
UnknownThe protein kinase 2 inhibitor CX-4945 regulates osteoclast and osteoblast differentiation in vitro.
Not available
S-EPMC3887940 | biostudies-literature
TranscriptomicsTranscriptome profiling of H295R adrenocortical carcinoma cells treated with the CK2/CLK inhibitor CX-4945 (silmitasertib)
Adrenocortical carcinoma is a rare and aggressive endocrine malignancy whose growth and hormonal output depend on the nuclear receptor NR5A1 (steroidogenic factor-1, SF-1), a transcription factor for which no ligand-based therapy is established. To ask whether the transcript rather than the protein ...
ORGANISM(S): Homo sapiens 
2022-06-24 | GSE133197 | GEO
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