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ProteomicsQuantification of Cardiac Troponin I Using ID-LC-MS/MSQuantification of Cardiac Troponin I Using ID-LC-MS/MS
An analytical protocol based on isotope dilution liquid chromatography-tandem mass spectrometry (ID-LC-MS/MS) which includes a peptide-based calibration strategy was developed and validated for accurate determination of cardiac troponin I (cTnI) levels in clinical samples.
ORGANISM(S): Homo sapiens (Human) 
2025-04-08 | PXD055104 | Pride
Picaa Immunoaffinity enrichment Peptide-based calibration Id-ms Ctni Magnetic particles 
GenomicsTranscriptome analysis of heart tissue in wild type and cTnI R193H mutation mice based on RNA-seq
Transcriptome analysis of heart tissue in wild type and cTnI R193H mutation mice based on RNA-seq
PRJNA610235 | ENA
ProteomicsTruncation of the N-terminus of cardiac troponin I initiates adaptive remodeling of the myocardial proteosome via phosphorylation of mechano-sensitive signaling pathways
We employed isobaric labeled peptides to do bottom-up proteomics to quantify both non-enriched total peptides and enriched phospho-peptides obtained from hearts of control mice expressing wild-type cardiac troponin I and transgenic mice expressing the truncated N-terminal cardiac troponin I.
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2021-03-15 | MSV000087049 | MassIVE
TranscriptomicsTranscriptome analysis of heart tissue in wild type and cTnI R193H mutation mice based on RNA-seq
Aim:To explore the pathogenesis of restrictive cardiomyopathy (RCM) with cTnI mutation by using RNA-Seq to detect differentially expressed genes in WT and cardiac troponin I (cTnI) mutation mouse heart. Methods: The heart of WT mice and cTnI 193H mutant mice were extracted, all mRNA of myocardial ti...
ORGANISM(S): Mus musculus 
2023-02-28 | GSE146355 | GEO
ProteomicsNanoproteomics enables proteoform-resolved analysis of low-abundance proteins in human serum
Top-down mass spectrometry (MS)-based proteomics provides a comprehensive analysis of proteoforms to achieve a proteome-wide understanding of protein functions. However, the MS detection of low-abundance proteins from the blood remains an unsolved challenge due to the complexity and extraordinary dy...
ORGANISM(S): Homo sapiens (Human) 
2020-09-11 | PXD019712 | Pride
Human Cardiac troponin i Qtof Serum Lc-ms Heart Maxis 
UnknownChemiluminescence Biosensor for the Determination of Cardiac Troponin I (cTnI).
Not available
S-EPMC10136549 | biostudies-literature
UnknownBiological Recognition-Based Electrochemical Aptasensor for Point-of-Care Detection of cTnI.
Not available
S-EPMC10377036 | biostudies-literature
UnknownArg92Leu-cTnT Alters the cTnC-cTnI Interface Disrupting PKA-Mediated Relaxation.
Not available
S-EPMC11502267 | biostudies-literature
UnknownHigh-sensitive cardiac troponin I (hs-cTnI) concentrations in newborns diagnosed with spinal muscular atrophy.
Not available
S-EPMC10687177 | biostudies-literature
UnknownDifferential analysis of transient increases of serum cTnI in response to handling in rats.
Not available
S-EPMC4186429 | biostudies-literature
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