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ProteomicsThe self-association equilibrium of DNAJA2 regulates its interaction with unfolded substrate proteins and with Hsc70
J-domain proteins tune the specificity of Hsp70s, engaging them in precise functions. Despite their essential role, the structure and function of many J-domain proteins remain largely unknown. We explore human DNAJA2, a class A J-domain protein, finding that it reversibly oligomerises into highly-or...
ORGANISM(S): Homo sapiens (Human) 
2023-09-05 | PXD043837 | Pride
Dnaja2 structure Chaperone Hsp70 system J-domain proteins Protein folding 
ProteomicsStructures of the 26S proteasome in complex with the Hsp70 cochaperone Bag1 reveal a novel mechanism for direct transfer of substrates to the catalytic chamber
Coupling of the degradation and chaperone systems, particularly under cellular stress, is essential for eliminating unfolded proteins. The co-chaperone Bag1 links the Hsp70 chaperone to the 26S proteasome, recruiting Hsp70-bound unfolded proteins for proteasomal degradation. Here, we present cryo-EM...
ORGANISM(S): Homo sapiens (Human) Saccharomyces cerevisiae (Baker's yeast) 
2025-12-23 | PXD069071 | Pride
Chaperones Degradation Hsp70 Bag1 Proteasome 
UnknownCryoEM structural characterization of α-Synuclein Oligomer
Not available
EMPIAR-12651 | biostudies-other
UnknownCryoEM structural characterization of α-Synuclein Oligomers in complex with PSMa3 peptide
Not available
EMPIAR-12657 | biostudies-other
UnknownClinical Characterization of Patients With Autosomal Dominant Short Stature due to Aggrecan Mutations.
Not available
S-EPMC5413162 | biostudies-literature
UnknownRenal Replacement Therapy in Lupus Nephritis-Related End-Stage Kidney Disease: A Systematic Review and Meta-Analysis.
Not available
S-EPMC12648630 | biostudies-literature
UnknownNon-structural carbohydrates mediate seasonal water stress across Amazon forests.
Not available
S-EPMC8055652 | biostudies-literature
UnknownSARS-CoV-2 vaccination modelling for safe surgery to save lives: data from an international prospective cohort study.
Not available
S-EPMC7995808 | biostudies-literature
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