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ProteomicsLinkage of oxidative stress and mitochondrial dysfunctions to spontaneous culture degeneration in Aspergillus nidulans
Filamentous fungi including mushrooms frequently and spontaneously degenerate during subsequent culture maintenance on artificial media, which shows the loss or reduction abilities of asexual sporulation, sexuality, fruiting and production of secondary metabolites, thus leading to economic losses du...
ORGANISM(S): Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans) 
2019-11-25 | PXD000422 | Pride
Mitochondrial proteomics Aspergillus nidulans Culture degeneration 
TranscriptomicsAnalysis of Meniscal Degeneration and Meniscal Gene Expression
Menisci play a vital role in load transmission, shock absorption and joint stability. The current dogma is that the menisci simply protects the cartilage and play no role in osteoarthritis (OA) unless they are injured. However, there is increasing evidence suggesting that OA menisci may not merely ...
ORGANISM(S): Homo sapiens 
2009-11-17 | E-GEOD-19060 | biostudies-arrayexpress
TranscriptomicsReversal of persistent wound-induced retinal pigmented epithelial-to-mesenchymal transition by the TGFb pathway inhibitor, A-83-01.
Age-related macular degeneration (AMD) is a leading cause of blindness. Most vision loss occurs following the transition from a disease of deposit formation and inflammation to a disease of neovascular fibrosis and/or cell death. Here, we investigate how repeated wound stimulus leads to seminal chan...
ORGANISM(S): Homo sapiens 
2015-07-06 | E-GEOD-67898 | biostudies-arrayexpress
ProteomicsStructural plasticity of actin-spectrin membrane skeleton and functional role of actin and spectrin in axon degeneration
Axon degeneration sculpts precise patterns of connectivity in the developing nervous system and is an early pathological hallmark of several adult-onset neurodegenerative disorders. Substantial progress has been made in identifying effector mechanisms that drive axon fragmentation, but far less is k...
ORGANISM(S): Mus musculus (Mouse) 
2019-03-14 | PXD009854 | Pride
Proteomics Axon degeneration Phosphorylation 
TranscriptomicsChemokine expression in retinal pigment epithelial cells in response to co-culture with activated T Cells
Purpose: To investigate the effects of T cell-derived cytokines on gene and protein expression of chemokines in a human RPE cell line (ARPE-19). Methods: We used an in vitro co-culture system in which the RPE and CD3/28-activated T cells were separated by a membrane. Differential gene expression in...
ORGANISM(S): Homo sapiens 
2012-11-19 | E-GEOD-36331 | biostudies-arrayexpress
UnknownCell culture model that mimics drusen formation and triggers complement activation associated with age-related macular degeneration.
Not available
S-EPMC3215058 | biostudies-literature
TranscriptomicsMolecular Response of Chorioretinal Endothelial Cells to Complement Injury: Implications for Macular Degeneration
Age-related macular degeneration (AMD) is a common, blinding disease of the elderly in which macular photoreceptor cells, retinal pigment epithelium, and choriocapillaris endothelial cells ultimately degenerate. Recent studies have found that degeneration of the choriocapillaris occurs early in this...
ORGANISM(S): Macaca mulatta 
2015-11-04 | E-GEOD-70806 | biostudies-arrayexpress
TranscriptomicsDegeneration of penicillin production in ethanol-limited chemostat cultivation of Penicillium chrysogenum: A systems biology approach
In microbial production of non-catabolic products, a loss of production capacity upon long-term cultivation (for example, chemostat), a phenomenon called strain degeneration, is nearly always observed. In this study, a systems biology approach (monitoring changes from gene to produced flux) was used...
ORGANISM(S): Penicillium chrysogenum 
2011-06-10 | E-GEOD-24212 | biostudies-arrayexpress
UnknownLinkage of oxidative stress and mitochondrial dysfunctions to spontaneous culture degeneration in Aspergillus nidulans.
Not available
S-EPMC3916646 | biostudies-literature
ProteomicsProteomic analysis of ARPE-19 cells exposed to chronic H2O2 treatment
We performed a proteomic analysis of a retinal pigment epithelium cell line (ARPE-19) exposed to long-term sublethal levels of H2O2 to mimic low-level pro-oxidative insult in age-related macular degeneration (AMD). using a wide range of biochemical analyses and cell culture techniques, we highlighte...
ORGANISM(S): Homo sapiens (Human) 
2021-01-04 | PXD022545 | Pride
Arpe-19 Retinal pigment epithelium Oxidative stress Macular degeneration 
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