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MetabolomicsMetabolomics guides rational development of a simplified cell culture medium for drug screening against Trypanosoma brucei
In vitro culture methods underpin many experimental approaches to biology and drug discovery. The modification of established cell culture methods to be more biologically relevant, or to optimise growth, is traditionally a laborious task. Emerging metabolomics technology enables rapid evaluation of ...
2015-05-14 | MTBLS49 | MetaboLights
MetabolomicsLiquid chromatography coupled to high-resolution mass spectrometry metabolomics: A useful tool for investigating tumor secretome based on a three-dimensional co-culture model

Three-dimensional (3D) cell culture technologies, which more closely mimic the complex microenvironment of tissue, are being increasingly evaluated as a tool for the preclinical screening of clinically promising new molecules, and studying of tissue metabolism. Studies of metabolites released int...

2023-12-12 | MTBLS5375 | MetaboLights
MetabolomicsAnalysis of Volatile Organic Compounds (VOCs) in Streptomyces sp. 30177 treated with cell-free filtrate of Sphingomonas sp. 06703 using Headspace Solid-Phase Microextraction (HS-SPME) coupled with Gas Chromatography-Mass Spectrometry (GC-MS)
This study aimed to analyze the volatile organic compounds (VOCs) produced by Streptomyces sp. 30177 in response to treatment with the cell-free filtrate of Sphingomonas sp. 06703. The cell-free filtrate was prepared by culturing Sphingomonas sp. 06703 in liquid medium, followed by centrifugation an...
2026-07-23 | MTBLS14913 | MetaboLights
MetabolomicsMetabolomic signatures in blastocyst spent culture medium as noninvasive predictors of live birth: a pilot study

Research Question: Can metabolomic profiling of blastocyst spent culture medium (SCM) serve as a non-invasive tool to predict live birth?

Design: This pilot study investigated the association between metabolite profiles in SCM and clinical outcomes following single blastocyst transfer. Seve...

2026-02-13 | MTBLS13898 | MetaboLights
MetabolomicsAlterations in the metabolic footprint induced by Mayaro virus infection in cell culture
This study focuses metabolic footprinting of Vero cells infected by Mayaro virus. Nuclear magnetic resonance combined with multivariate analytical methods and tools of pattern recognition shows that metabolic changes can be attributed to the effect of Mayaro virus infection. Vero cells infected by M...
2021-10-28 | MTBLS639 | MetaboLights
ProteomicsThe effect of entomopathogenic fungal culture filtrate on the immune response and haemolymph proteome of the large pine weevil, Hylobius abietis.
The large pine weevil Hylobius abietis L. is a major forestry pest in 15 European countries, where it is a threat to 3.4 million hectares of forest. A cellular and proteomic analysis of the effect of culture filtrate of three entomopathogenic fungi (EPF) species on the immune system of H. abietis wa...
ORGANISM(S): Hylobius abietis 
2018-07-23 | PXD008232 | Pride
Proteomics Entomopathogenic fungi Lfq Pine weevil Immune response 
MetabolomicsInvestigating the Impact of Acinetobacter lwoffii-ECT1/E6E7 Co-culture Metabolites on Cervical Cell Proliferation and Apoptosis via Untargeted Metabolomics.

This study employed untargeted metabolomics detection combined with bioinformatics analysis to investigate the metabolites from the co-culture of Acinetobacter lwoffiiand cervical precancerous cells ECT1/E6E7. A. lwoffiiwas co-cultured with ECT1/E6E7 cells at an MOI of 100. The culture supernatan...

2025-12-17 | MTBLS13526 | MetaboLights
ProteomicsProteomics analysis of mycobacterium marinum culture filtrate
Mycobacterium marinum is a pathogenic bacterium that causes infections in both fish and humans. The PE/PPE protein family is unique to mycobacteria and has been implicated in various aspects of mycobacterial pathogenicity. Understanding the presence and potential function of these proteins in M. mar...
ORGANISM(S): Mycobacterium marinum (strain ATCC BAA-535 / M) 
2025-05-13 | PXD050612 | Pride
Mycobacterium marinum Lc-ms Culture filtrate 
ProteomicsCulture filtrate of Mycobacterium tuberculosis clinical isolate S169 DIA
Phagosome acidification is one of the challenges faced by Mycobacterium tuberculosis during infection. This intracellular pathogen is known to adapt to its stressful environment through stress response pathways and by secreting proteins to modify the host immune response for survival and proliferati...
ORGANISM(S): Mycobacterium tuberculosis H37Rv 
2026-02-13 | PXD073840 | Pride
Tuberculosis Stress Dia 
ProteomicsProteomic profiling of Mycobacterium tuberculosis culture filtrate identifies novel O-glycosylated proteins
Integrative evaluation of M. tuberculosis culture filtrate proteins and O-glycosylation profile analysis. Shotgun analysis of culture filtrate proteins of M. tuberculosis based on a liquid nano-HPLC tandem mass spectrometry and a label-free spectral counting normalization approach for protein quanti...
ORGANISM(S): Mycobacterium Tuberculosis (ncbitaxon:1773) 
2019-08-08 | MSV000084184 | MassIVE
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