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TranscriptomicsComparison of transcriptomes between DMSO-5uM and Torin1-5uM treated mouse cumulus-oocyte complexes cultured in vitro for 14h
We sought to identify the potential specific roles of the MTOR signalling in cumulus cells by comparing the transcriptomes of the Control (treated with the DMSO vehicle) and MTOR-specific inhibitor Torin 1(5uM)-treated cumulus-oocyte complexes that were cultured for 16 hours. We compared the transcr...
ORGANISM(S): Mus musculus 
2016-08-01 | E-GEOD-79862 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of cumulus cell oocyte complexes isolated at different time points of ovulation to identify differentially expressed genes.
Cumulus-oocyte complexes were isolated at seperate time-points to generate temporal complexes. Targets from two biological replicates at each time point (0h, 8h, 16h post-hCG treatment) were generated and the expression profiles were determined using Affymetrix GeneChip Mouse Genome 430 2.0 Arrays....
ORGANISM(S): Mus musculus 
2007-11-06 | E-GEOD-4260 | biostudies-arrayexpress
ProteomicsPalmitoylated proteins in bovine ovarian cumulus-oocyte complexes
The palmitoyl-proteome of bovine cumulus-oocyte complexes (COCs) cells was investigated by combining acyl-biotin exchange chemistry and quantitative mass spectrometry analysis.
ORGANISM(S): Bos taurus (Bovine) 
2022-02-15 | PXD020540 | Pride
Bovine Palmitoylation Cumulus-oocyte complexes 
TranscriptomicsBovine adult versus prepubertal cumulus cells
The present study was undertaken to discover molecular markers in bovine cumulus cells predictive of oocyte competence and elucidate their functional significance. Differences in RNA transcript abundance in cumulus cells harvested from oocytes of adult versus prepubertal animals (model of poor oocy...
ORGANISM(S): Bos taurus 
2010-05-25 | E-GEOD-10819 | biostudies-arrayexpress
ProteomicsThe bovine cumulus proteome of cumulus oocyte complexes that successfully matured or failed to mature after maturation in-vitro and in-vivo
The oocyte forms a complex with their somatic cumulus cells within the follicle throughout the preovulatory maturation steps. Cumulus cells support their oocyte not only through mechanical protection but also with a close bidirectional exchange of metabolites. Analysis of the oocytes cumulus gives t...
ORGANISM(S): Bos taurus (Bovine) 
2020-06-30 | PXD016679 | Pride
Cumulus Proteomics Oocyte 
ProteomicsMulti-omics reveal the metabolic patterns in mouse cumulus cells during oocyte maturation
Bi-directional communication between cumulus cells and the surrounded oocytes is important for the development and functions of both compartments. However, the metabolic framework in cumulus cells has not been systematically described. In the present study, cumulus cells from cumulus-oocyte complex...
ORGANISM(S): Mus Musculus 
2023-03-10 | PXD040796 |
TranscriptomicsSAGE in Cultured Murine COC During Early Maturation
In cultured cumulus oocyte complexes (COC) FSH induces gene transcription required for germinal vesicle breakdown (GVBD). Experiments were performed to determine the critical period when gene transcription is required for GVBD and identify candidate mRNAs involved. Experiment I: murine COC were cult...
ORGANISM(S): Mus musculus 
2006-08-31 | E-GEOD-5568 | biostudies-arrayexpress
TranscriptomicsExtensive effects of in vitro oocyte maturation on rhesus monkey cumulus cell transcriptome
The elaboration of a quality oocyte is integrally linked to the correct developmental progression of cumulus cell phenotype. In humans and non-human primates, oocyte quality is diminished with in vitro maturation. To determine the changes in gene expression in rhesus monkey cumulus cells (CC) that o...
ORGANISM(S): Macaca mulatta 
2011-05-22 | E-GEOD-25288 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse cumulus cells from Bmp15-/- and Bmp15-/-Gdf9+/--DM animals
Mouse oocytes control cumulus cell metabolic processes that are deficient in the oocytes themselves and this delegation is necessary for oocyte development. Oocyte-derived bone morphogenetic factor 15 (BMP15) and growth differentiation factor 9 (GDF9) appear to be key regulators of follicular devel...
ORGANISM(S): Mus musculus 
2008-06-15 | E-GEOD-7225 | biostudies-arrayexpress
ProteomicsMulti-Omics Profiling Uncovers Metabolic Regulation in Cumulus Cells During Oocyte Maturation
Multi-Omics Profiling Uncovers Metabolic Regulation in Cumulus Cells During Oocyte Maturation
ORGANISM(S): Bos Taurus 
PXD068708 |
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