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ProteomicsMultiple sclerosis cuprizone mouse model and vitamin D supplementation
Dietary supplementation of vitamin D is commonly recommended to patients with multiple sclerosis (MS). We investigated the effect of 1,25-dihydroxyvitamin-D3 (1,25-(OH)2D3) on the brain proteome in the cuprizone model during remyelination. Mice were demyelinated with dietary cuprizone for 7 weeks. T...
ORGANISM(S): Mus musculus (Mouse) 
2017-08-16 | PXD002347 | Pride
Mouse Multiple sclerosis Vitamin d Cuprizone tmt 
ProteomicsMultiple sclerosis resaerch: EAE and cuprizone mouse brain TMT and label-free proteomics
Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system, and in this study we used quantitative proteomics to compare the brain proteomes of two MS mouse models, the immune-mediated experimental autoimmune encephalomyelitis (acute and recovery phase) and...
ORGANISM(S): Mus musculus (Mouse) 
2021-03-16 | PXD002318 | Pride
Orbitrap velos Mus musculus Brain Tmt Label-free 
ProteomicsBrain proteome analysis after 6 weeks of cuprizone or normal diet and 3 weeks of 40 Hz stimlation.
Brain proteome analysis after 6 weeks of cuprizone or normal diet and 3 weeks of 40 Hz stimlation or constant light and sound (control groups).
ORGANISM(S): Mus musculus (Mouse) 
2024-06-07 | PXD044572 | Pride
Cuprizone Mouse Tmt Genus 
ProteomicsFingolimod and remyelination - Fingolimod downregulates brain sphingosine-1-phosphate receptor 1 levels but does not promote remyelination or neuroprotection in the cuprizone model
Remyelinating substances could be an essential supplement to immunomodulatory medications, optimizing the treatment of multiple sclerosis (MS) patients. Fingolimod is a sphingosine-1-phosphate receptor (S1PR) modulator and crosses the blood-brain barrier. Central nervous system (CNS) cells express S...
ORGANISM(S): Mus musculus (Mouse) 
2019-11-20 | PXD012676 | Pride
Brain Cpz Tissue Proteomics Tmt Mass spectrometry Qe-hf Fingolimod Mouse Multiplexing 
UnknownCuprizone and EAE mouse frontal cortex proteomics revealed proteins altered in multiple sclerosis.
Not available
S-EPMC8010076 | biostudies-literature
UnknownUrsolic acid derivative UAOS-Na treats experimental autoimmune encephalomyelitis by immunoregulation and protecting myelin.
Not available
S-EPMC10723162 | biostudies-literature
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