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Proteomicso The CutRS two-component system controls the Streptomyces secretion stress response by monitoring extracellular disulphide bond formation
o Translocating unfolded proteins across cell membranes is essential in all domains of life and requires the conserved Sec machinery. In bacteria, Sec substrates fold on the extracellular face of the cytoplasmic membrane and misfolding triggers a stress response that involves production of HtrA-fami...
ORGANISM(S): Streptomyces venezuelae 
2025-08-09 | PXD051851 | Pride
Proteomics Two component systems Cutrs Streptomyces Secretion stress Regulation 
GenomicsEvidence of a role for CutRS and actinorhodin in the secretion stress response in Streptomyces coelicolor M145
CutRS was the first two-component system to be identified in Streptomyces species and is highly conserved in this genus. It was reported >25 years ago that deletion of cutRS increases the production of the antibiotic actinorhodin in Streptomyces coelicolor but despite this early work the function of...
ORGANISM(S): Streptomyces coelicolor 
2023-06-12 | GSE225370 | GEO
GenomicsEvidence of a role for CutRS and actinorhodin in the secretion stress response in Streptomyces coelicolor M145
Evidence of a role for CutRS and actinorhodin in the secretion stress response in Streptomyces coelicolor M145
PRJNA935355 | ENA
ProteomicsEvidence of a role for CutRS and actinorhodin in the secretion stress response in Streptomyces coelicolor M145
This work was carried out to elucidate the proteins that are regulated by the two-component system CutRS in Streptomyces coelicolor M145 and how this response changes in the presence of glucose. A comparison of the whole cell proteomes of Streptomyces coelicolor M145 WT and Streptomyces coelicolor M...
ORGANISM(S): Streptomyces coelicolor A3(2) 
2023-06-16 | PXD040579 | Pride
Antibiotics Streptomyces Two-component system Protein secretion Actinorhodin Secretion stress 
UnknownEvidence of a role for CutRS and actinorhodin in the secretion stress response in Streptomyces coelicolor M145.
Not available
S-EPMC10433416 | biostudies-literature
UnknownThe conserved two-component systems CutRS and CssRS control the protein secretion stress response in <i>Streptomyces</i>.
Not available
S-EPMC12802291 | biostudies-literature
UnknownTranslation of CircRNAs.
Not available
S-EPMC5387669 | biostudies-literature
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