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ProteomicsImmunoaffinity targeted mass spectrometry analysis of plasma samples reveals an imbalance of active and inactive CXCL10 in primary Sjögren’s Syndrome disease patients
One of the most important advantages of mass spectrometry is the ability to quantify proteins and their modifications in parallel to obtain a holistic picture of the protein of interest. Here, we present a hybrid immunoaffinity targeted mass spectrometry (MS) approach that combines efficient pan-ant...
ORGANISM(S): Homo sapiens (Human) 
2020-08-20 | PXD019709 | Pride
Cxcl10 Prm Primary sjögren’s syndrome Targeted ms Plasma 
ProteomicsPro-inflammatory Beta Cell Small Extracellular Vesicles Induce Beta Cell Failure Through Activation of the CXCL10/CXCR3 Axis in Diabetes
Coordinated communication among pancreatic islet cells is necessary for the maintenance of glucose homeostasis. In diabetes, chronic exposure to pro-inflammatory cytokines has been shown to perturb β-cell communication and function. Compelling evidence has implicated extracellular vesicles (EVs) in ...
ORGANISM(S): Mus musculus (Mouse) 
2021-08-25 | PXD026998 | Pride
Inflammation Β-cell Extracellular vesicles Intercellular communication Cxcl10 Diabetes 
ProteomicsViperin; regulating chondrogenic differentiation via CXCL10 protein secretion
Mutations in the RMRP gene are the origin of cartilage-hair hypoplasia. Cartilage-hair hypoplasia is associated with severe dwarfism caused by impaired skeletal development. However, it is not clear why mutations in the RMRP gene lead to skeletal dysplasia. Viperin is a known substrate of RMRP. Sinc...
ORGANISM(S): Mus musculus (Mouse) 
2019-02-15 | PXD006999 | Pride
Mouse Viperin Chondrogenic differentiation 
GenomicsThe effect of CXCL10 on macrophages
The effect of CXCL10 on macrophages
PRJNA1067633 | ENA
TranscriptomicsAnalysis of the early transcriptome signature of Nipah virus infection in primary endothelial cells
Nipah virus (NiV) is a recently emerged zoonotic Paramyxovirus that causes regular outbreaks in East Asia with mortality rate exceeding 75%. Major cellular targets of NiV infection are endothelial cells and neurons. To better understand virus-host interaction, we analysed the transcriptome profile o...
ORGANISM(S): Homo sapiens 
2012-08-24 | E-GEOD-32902 | biostudies-arrayexpress
TranscriptomicsTLR2/6 agonists and IFNgamma induce CXCL10 from melanoma
Clinical approaches to treat advanced melanoma include immune therapies, whose benefits depend on tumor-reactive T-cells to infiltrate metastases. However, most tumors lack significant immune infiltration prior to therapy, and some immune therapies are hindered by a persistent lack of immune cell in...
ORGANISM(S): Homo sapiens 
2015-11-22 | E-GEOD-64506 | biostudies-arrayexpress
GenomicsCXCL10 contributes to female-specific pathological progression in tauopathy model mice
CXCL10 contributes to female-specific pathological progression in tauopathy model mice
PRJNA1464714 | ENA
GenomicsCXCL10 contributes to female-specific pathological progression in tauopathy model mice
CXCL10 contributes to female-specific pathological progression in tauopathy model mice
PRJNA1465249 | ENA
GenomicsVehicle vs CXCL10 expression in 4MOSC1 buccal tumors
Vehicle vs CXCL10 expression in 4MOSC1 buccal tumors
PRJNA1256757 | ENA
GenomicsCxcl10 and Cxcr3 regulate self-renewal and differentiation of hematopoietic stem cells
Cxcl10 and Cxcr3 regulate self-renewal and differentiation of hematopoietic stem cells
PRJNA1138668 | ENA
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