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MetabolomicsTargeting transcription factor pu.1 for improving neurologic outcomes after spinal cord injury

Background: After spinal cord injury (SCI), lipid metabolism dysregulation at the lesion site exacerbates secondary damage. The transcription factor pu.1 has been implicated as a negative regulator of multiple lipid metabolism-related genes and pathways. However, its role in post-SCI lipid metabo...

2024-08-08 | MTBLS10453 | MetaboLights
ProteomicsInteractome analysis of Adenylyl cyclase-associated protein 1
The direct inflammatory action of proprotein convertase subtilisin/kexin type 9 (PCSK9) is examined in vitro in monocytes and endothelial cells, as well as via an in vivo atherosclerosis animal model. PCSK9 exacerbates atherosclerosis in low-density lipoprotein receptor (LDLR)-/- mice, indicating an...
ORGANISM(S): Homo sapiens (Human) 
2024-06-16 | PXD047058 | Pride
Cap1 Human Interactome Pcsk9 
TranscriptomicsExpression data from Shewanella oneidensis MR-1 wild-type, Δcrp, and ΔcyaC strains
Anaerobic respiration in the metal reducer Shewanella oneidensis MR-1, unlike other bacteria, is regulated by the cAMP receptor protein, CRP. Three putative genes, cyaA, cyaB, and cyaC, predicted to encode class I, class IV, and class III adenylate cyclases respectively, have been identified in the ...
ORGANISM(S): Shewanella oneidensis MR-1 
2010-06-19 | E-GEOD-15657 | biostudies-arrayexpress
UnknownCAS-1, a C. elegans cyclase-associated protein, is required for sarcomeric actin assembly in striated muscle.
Not available
S-EPMC3482317 | biostudies-literature
UnknownCyclase-associated protein 1 (CAP1) promotes cofilin-induced actin dynamics in mammalian nonmuscle cells.
Not available
S-EPMC404026 | biostudies-literature
UnknownAdenylyl cyclase-associated protein 1 is a receptor for human resistin and mediates inflammatory actions of human monocytes.
Not available
S-EPMC3969988 | biostudies-literature
TranscriptomicsTranscription profiling of human soluble guanylate cyclase-deficient U937 cells exposed to the nitric oxide (NO) donor S-nitrosoglutathione to provide insight into the cGMP-independent effects of NO
NO effects on gene expression, independent of cGMP, were examined globally. Differentiated human U937 cells that lack soluble guanylate cyclase were exposed to Snitrosoglutathione, a NO donor, or glutathione without or with dibutyryl-cAMP (Bt2cAMP). NO regulated 110 transcripts that annotated dispro...
ORGANISM(S): Homo sapiens 
2007-09-11 | E-GEOD-2649 | biostudies-arrayexpress
UnknownCyclase-associated protein 1 (CAP1) is a prenyl-binding partner of Rap1 GTPase.
Not available
S-EPMC5961064 | biostudies-literature
UnknownmiRNA mediated downregulation of cyclase-associated protein 1 (CAP1) is required for myoblast fusion.
Not available
S-EPMC9562714 | biostudies-literature
UnknownAdenylyl cyclase‑associated protein 1‑targeted nanoparticles as a novel strategy for the treatment of metastatic non‑small cell lung cancer.
Not available
S-EPMC6615927 | biostudies-literature
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