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TranscriptomicsCyclophilin D extramitochondrial signaling controls cell cycle progression and chemokine-directed cell motility.
Mitochondria control bioenergetics and cell fate decisions, but whether they also participate in extra-organelle signaling is not understood. Here, we show that interference with cyclophilin D (CypD), a mitochondrial matrix protein and apoptosis regulator, causes accelerated cell proliferation and ...
ORGANISM(S): Mus musculus 
2013-03-08 | E-GEOD-41280 | biostudies-arrayexpress
ProteomicsCyclophilin B deficiency causes abnormal dentin collagen matrix
To evaluate the effects of cyclophilin B deficiency on expression levels of collagen family members in dentin, we performed protein identification of cyclophilin B-WT, -Het, and -KO teeth after trypsin digestion.
ORGANISM(S): Mus Musculus (mouse) 
2017-07-20 | PXD006021 | JPOST Repository
TranscriptomicsAnalysis of Ppif-/- hearts
To identify differences in gene expression between peptidylprolyl isomerase F (cyclophilin D; Ppif)-null hearts and WT control hearts. RNA was isolated from mice 8 weeks of age to discover gene changes prior to myocardial dysfunction. Three replicates each of Ppif-/- and WT mice.
ORGANISM(S): Mus musculus 
2011-01-05 | E-GEOD-23028 | biostudies-arrayexpress
ProteomicsCyclophilin A isomerization of Septin 2 mediates abscission during cytokinesis
The isomerase activity of Cyclophilin A is important for midbody abscission during cell division, however to date, midbody substrates remain unknown. In this study, we report that the GTP-binding protein Septin 2 interacts with Cyclophilin A. We highlight a dynamic series of Septin 2 phenotypes at t...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD042822 | Pride
Human Cancer Cyclophilin a Cytokinesis Septin 2 K562 cells 
ProteomicsCyclophilin B function elucidated by electrochemical sensors
We have investigated the function of CypB through negative ionization high resolution LCMS and examined the purity of a CypB protein with intact mass analyzes on a Q Exactive mass spectrometer.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-05-19 | MSV000089498 | MassIVE
TranscriptomicsExpression of cyclophilin B is associated with malignant progression and regulation of genes
Microarray was conducted on Illumina Human Ref-6 Version 2 Expression Chip (Illumina, San Diego, CA). Three independent cultures were used for RNA isolation with RNeasy plus mini kit (Qiagen, Valencia, CA). RNA quality was checked by Agilent Bioanalyzer (Agilent, Santa Clara, CA). An Ambion labelin...
ORGANISM(S): Homo sapiens 
2009-04-03 | E-GEOD-15505 | biostudies-arrayexpress
TranscriptomicsCyclophilin B supports the survuval of glioblastoma multiforme cells
We have found that cyclophilin B (CypB) expression is important for malignant glioblastoma multiforme (GBM) cell proliferation. To identify molecular mechanisms that could explain CypB-dependent survival in human GBM cells, a microarray analysis was performed using RNA prepared from U251MG GBM cells...
ORGANISM(S): Homo sapiens 
2013-09-12 | E-GEOD-50756 | biostudies-arrayexpress
GenomicsPrecision Editing of Cyclophilin A Generates Cyclosporine and Voclosporin Resistant Cellular Therapies
Precision Editing of Cyclophilin A Generates Cyclosporine and Voclosporin Resistant Cellular Therapies
PRJNA1454422 | ENA
TranscriptomicsTranscription profiling of primary lung cells to identify targets of the novel Rho GTPase RhoBTB2.
RhoBTB2 is a novel Rho GTPase that undergoes loss, underexpression and mutation in breast and lung cancer. We have shown that we can mimic loss of RhoBTB2 through siRNA treatment of primary cells. We propose to perform comparative microarray analysis of primary lung cells to establish the identifica...
ORGANISM(S): Homo sapiens 
2008-10-25 | E-GEOD-8837 | biostudies-arrayexpress
TranscriptomicsPost-transcriptional generation of miRNA variants by multiple nucleotidyl transferases contributes to miRNA transcriptome complexity (KD)
Modification of microRNA sequences by the 3' addition of nucleotides to generate so-called “isomiRs” adds to the complexity of miRNA function, with recent reports showing that 3' modifications can influence miRNA stability and efficiency of target repression. Here we show that the 3' modification of...
ORGANISM(S): Homo sapiens 
2011-06-15 | E-GEOD-26803 | biostudies-arrayexpress
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