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ProteomicsHuman mitochondrial cysteine desulfurase complex
Cysteine desulfurase plays central role in mitochondrial iron-sulfur cluster biogenesis not only by providing sulfur through the catalysis of L-cysteine to L-alanine but also by serving as the platform for the assembly of other components of the biosynthetic machinery, including ISCU, frataxin, and ...
ORGANISM(S): Homo sapiens (Human) 
2018-07-11 | PXD009079 | Pride
Human Cysteine desulfurase Cx-ms 
ProteomicsHuman mitochondrial cysteine desulfurase complex data set 2
Cysteine desulfurase plays central role in mitochondrial iron-sulfur cluster biogenesis not only by providing sulfur through the catalysis of L-cysteine to L-alanine but also by serving as the platform for the assembly of other components of the biosynthetic machinery, including ISCU, frataxin, and ...
ORGANISM(S): Homo sapiens (Human) 
2022-03-25 | PXD009128 | Pride
Mitochondrial cysteine desulfurase Xc-ms 
ProteomicsOverlapping binding site for ferredoxin and frataxin on yeast cysteine desulfurase participating in FeS cluster biogenesis
In mitochondria cysteine desulfurase (Nfs1) plays a central role in the biosynthesis of iron-sulfur (FeS) clusters, cofactors critical for activity of many cellular proteins. Nfs1 functions both as a sulfur donor for cluster assembly and as a binding platform for other proteins functioning in the pr...
ORGANISM(S): Escherichia coli Saccharomyces cerevisiae (Baker's yeast) 
2022-04-04 | PXD029519 | Pride
Lc-msms Protein complex Iron-sulfur protein 
UnknownCysteine desulfurase is regulated by phosphorylation of Nfs1 in yeast mitochondria.
Not available
S-EPMC5858965 | biostudies-literature
UnknownA novel cysteine desulfurase influencing organosulfur compounds in Lentinula edodes.
Not available
S-EPMC4460571 | biostudies-literature
ProteomicsD-Cysteine impairs tumour growth by inhibiting cysteine desulfurase NFS1
Selective targeting of cancer cells is a major challenge for cancer therapy. Many cancer cells overexpress the cystine/glutamate antiporter xCT/CD98, a transport system that imports L-cystine to strengthen antioxidant defenses, thereby promoting tumour survival and progression. We have exploited thi...
ORGANISM(S): Homo sapiens (Human) 
2025-09-01 | PXD063479 | Pride
Iron-sulfur cluster Iron-sulfur protein biogenesis Iron homeostasis. Cancer Amino acid 
UnknownArchitectural Features of Human Mitochondrial Cysteine Desulfurase Complexes from Crosslinking Mass Spectrometry and Small-Angle X-Ray Scattering.
Not available
S-EPMC6082693 | biostudies-literature
UnknownD-cysteine impairs tumour growth by inhibiting cysteine desulfurase NFS1.
Not available
S-EPMC12373508 | biostudies-literature
UnknownMitochondrial Cysteine Desulfurase and ISD11 Coexpressed in Escherichia coli Yield Complex Containing Acyl Carrier Protein.
Not available
S-EPMC5404276 | biostudies-literature
UnknownCyaY and TusA regulate ISC- and SUF-mediated l-cysteine desulfurase activity.
Not available
S-EPMC11446229 | biostudies-literature
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