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ProteomicsCysteine oxidation as a regulatory mechanism of Arabidopsis plastidial NAD-dependent malate dehydrogenase
Malate dehydrogenases (MDHs) catalyze a reversible NAD(P)-dependent-oxidoreductase reaction that plays an important role in central metabolism and redox homeostasis of plant cells. Recent studies suggest a moonlighting function of plastidial NAD-dependent MDH (plNAD-MDH) in plastid biogenesis, indep...
ORGANISM(S): Escherichia Coli 
2024-04-29 | PXD048384 | JPOST Repository
ProteomicsCombining redox proteomics with proximity labeling to monitor localized cysteine oxidation
Reactive oxygen species (ROS) can modulate protein function through cysteine oxidation. Identifying targets of ROS can provide insight into uncharacterized ROS-regulated pathways. Several redox-proteomic workflows, such as OxICAT, exist to identify sites of cysteine oxidation. However, determining R...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2024-05-21 | PXD034118 | Pride
Cysteine oxidation Apex Reactive oxygen species Oxicat Turboid Proximity labeling 
ProteomicsIntegrated Dissection of Cysteine Oxidative Modification Proteome During Cardiac Hypertrophy
Cysteine oxidative modification of cellular proteins is crucial for many aspects of cardiac hypertrophy development. However, integrated dissection of multiple types of cysteine oxidation proteome in cardiac hypertrophy is currently missing. Here we developed a novel discovery platform encompassing ...
ORGANISM(S): Mus musculus (Mouse) 
2018-08-29 | PXD010336 | Pride
Mouse Cardiac hypertrophy Heart Biotin switch Dimethyl labeling Cysteine oxidation Reversible cysteine oxidation Cysteine sulfinylation Cysteine sulfonylation Quantitative proteomics 
ProteomicsCysteine oxidation triggers amyloid fibril formation of the tumor suppressor p16INK4A
p16INK4A inhibits the CDK4/6 kinases and is therefore an important cell cycle regulator. Accumulation of p16INK4A in response to oncogenic transformation leads to cellular senescence and it is therefore frequently lost in cancer. p16INK4A is also known to accumulate under conditions of cellular oxid...
ORGANISM(S): Homo sapiens (Human) 
2019-09-04 | PXD012353 | Pride
Cysteine oxidation amyloid fibril p16ink4a 
ProteomicsSupporting information for tryptic EPO glycopeptide LC-MS analysis via cysteine aminoethylation
Supplementary information for a technical note describing the application of cysteine aminoethylation for the site-specific glycosylation analysis of recombinant human EPO using trypsin as sole protease.
ORGANISM(S): Cho Cells 
2020-04-21 | MSV000085318 | MassIVE
ProteomicsProteome-wide analysis of cysteine oxidation reveals metabolic sensitivity to redox stress, PART 1
Reactive oxygen species (ROS) are increasingly recognised as important regulators of cellular biology through the oxidative modification of protein cysteine residues. Comprehensive identification of redox-regulated proteins and cellular pathways are crucial to understand ROS-mediated events. Here, w...
ORGANISM(S): Mus musculus (Mouse) 
2018-03-06 | PXD006363 | Pride
Oxidative stress High ph fractionation Proteome Orbitrap hf Ros Mouse kidney tissue fumarate hydratase (fh) deficient Dimethyl labeling Primary immortalised kidney epithelial cells fumarate hydratase (fh) deficient Cysteine oxidation quantitation 
ProteomicsProteome-wide analysis of cysteine oxidation reveals metabolic sensitivity to redox stress, PART 2
Reactive oxygen species (ROS) are increasingly recognised as important regulators of cellular biology through the oxidative modification of protein cysteine residues. Comprehensive identification of redox-regulated proteins and cellular pathways are crucial to understand ROS-mediated events. Here, w...
ORGANISM(S): Mus musculus (Mouse) 
2018-03-06 | PXD006372 | Pride
Oxidative stress High ph fractionation Proteome Orbitrap hf Ros Mouse kidney tissue fumarate hydratase (fh) deficient Dimethyl labeling Primary immortalised kidney epithelial cells fumarate hydratase (fh) deficient Cysteine oxidation quantitation 
ProteomicsProteome-wide analysis of cysteine oxidation reveals metabolic sensitivity to redox stress, PART 3
Reactive oxygen species (ROS) are increasingly recognised as important regulators of cellular biology through the oxidative modification of protein cysteine residues. Comprehensive identification of redox-regulated proteins and cellular pathways are crucial to understand ROS-mediated events. Here, w...
ORGANISM(S): Mus musculus (Mouse) 
2018-03-06 | PXD006373 | Pride
Oxidative stress High ph fractionation Proteome Orbitrap hf Ros Mouse kidney tissue fumarate hydratase (fh) deficient Dimethyl labeling Primary immortalised kidney epithelial cells fumarate hydratase (fh) deficient Cysteine oxidation quantitation 
ProteomicsCysQuant: simultaneous quantification of cysteine oxidation and protein abundance using data dependent or independent acquisition mass spectrometry
Protein cysteinyl thiols are susceptible to reduction-oxidation reactions that can influence protein function, urging the need for accurate cysteine oxidation quantification to decode protein redox regulation. Here, we present a novel approach called CysQuant that enables simultaneous quantification...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2023-07-21 | PXD043895 | Pride
Cysteine oxidation Redox Data-independent acquisition Plexdia 
ProteomicsChemical inhibition of the target of rapamycin kinase in Chlamydomonas reinhardtii leads to rapid cysteine oxidation and sustained physiological changes.
The target of rapamycin (TOR) kinase is a key metabolic regulator with a role in diverse processes, including nutritional sensing, protein translation, and autophagy. In the green alga Chlamydomonas reinhardtii, TOR maintains these responsibilities and is additionally linked to the regulation of inc...
ORGANISM(S): Chlamydomonas reinhardtii 
2019-10-04 | PXD014819 | Pride
Azd8055 Global proteomics Chlamydomonas reinhardtii Target of rapamycin Reversible cysteine oxidation 
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