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ProteomicsDisruption of the human Cystin-1 myristoyl-electrostatic switch causes autosomal recessive polycystic kidney disease (ARPKD)
Autosomal recessive polycystic kidney disease (ARPKD; MIM#263200) is primarily caused by pathogenic variants in PKHD1, which encodes fibrocystin/polyductin (FPC). The Cys1cpk/cpk (cpk) mouse expresses a renal lesion that closely phenocopies ARPKD. Cys1-encoded cystin is a myristoylated protein that ...
ORGANISM(S): Mus musculus (Mouse) 
2026-04-13 | PXD048013 | Pride
Arpkd Myristoyl-electrostatic switch Pka-phosphorylation Ppm1a-dephosphorylation Cystin Cystin-1 
UnknownThe ciliary protein cystin forms a regulatory complex with necdin to modulate Myc expression.
Not available
S-EPMC3859662 | biostudies-literature
UnknownCystin genetic variants cause autosomal recessive polycystic kidney disease associated with altered Myc expression.
Not available
S-EPMC8440558 | biostudies-literature
UnknownCystin, a novel cilia-associated protein, is disrupted in the cpk mouse model of polycystic kidney disease.
Not available
S-EPMC150876 | biostudies-literature
UnknownCystin is required for maintaining fibrocystin (FPC) levels and safeguarding proteome integrity in mouse renal epithelial cells: A mechanistic connection between the kidney defects in cpk mice and human ARPKD.
Not available
S-EPMC10929748 | biostudies-literature
UnknownA classification of ductal plate malformations based on distinct pathogenic mechanisms of biliary dysmorphogenesis.
Not available
S-EPMC4271518 | biostudies-literature
UnknownHexapod Assassins' Potion: Venom Composition and Bioactivity from the Eurasian Assassin Bug Rhynocoris iracundus.
Not available
S-EPMC8301361 | biostudies-literature
UnknownCharacterization of PKD protein-positive exosome-like vesicles.
Not available
S-EPMC2637052 | biostudies-literature
TranscriptomicsBA-Methionine plus Cystine vs Cystine
Study of sulfur metabolism in BA 2 biologic replicates
ORGANISM(S): Brevibacterium aurantiacum 
2010-11-25 | E-GEOD-25418 | biostudies-arrayexpress
TranscriptomicsC. perfringens 13 strain vs 13?cpe1786 erm strain
Transcriptional profiling of C. perfringens 13 strain compared with strain 13?cpe1786 erm after growth in minimal medium with 0.5 mM cystine. two-condition experiment, 13 vs 13?cpe1786 erm, 4 biological replicates for each condition
ORGANISM(S): Clostridium perfringens 
2010-10-01 | E-GEOD-19359 | biostudies-arrayexpress
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