Sort   by:  
 Page size 
ProteomicsDisruption of the human Cystin-1 myristoyl-electrostatic switch causes autosomal recessive polycystic kidney disease (ARPKD)
Autosomal recessive polycystic kidney disease (ARPKD; MIM#263200) is primarily caused by pathogenic variants in PKHD1, which encodes fibrocystin/polyductin (FPC). The Cys1cpk/cpk (cpk) mouse expresses a renal lesion that closely phenocopies ARPKD. Cys1-encoded cystin is a myristoylated protein that ...
ORGANISM(S): Mus musculus (Mouse) 
2026-04-13 | PXD048013 | Pride
Arpkd Myristoyl-electrostatic switch Pka-phosphorylation Ppm1a-dephosphorylation Cystin Cystin-1 
UnknownA classification of ductal plate malformations based on distinct pathogenic mechanisms of biliary dysmorphogenesis.
Not available
S-EPMC4271518 | biostudies-literature
UnknownCharacterization of PKD protein-positive exosome-like vesicles.
Not available
S-EPMC2637052 | biostudies-literature
TranscriptomicsC. perfringens 13 strain vs 13?cpe1786 erm strain
Transcriptional profiling of C. perfringens 13 strain compared with strain 13?cpe1786 erm after growth in minimal medium with 0.5 mM cystine. two-condition experiment, 13 vs 13?cpe1786 erm, 4 biological replicates for each condition
ORGANISM(S): Clostridium perfringens 
2010-10-01 | E-GEOD-19359 | biostudies-arrayexpress
TranscriptomicsSynthetic cystine addiction via programmed necrosis in VHL-deficient renal cell carcinoma
Altered metabolism is an important part of malignant transformation of tumor cells. Oncogenic transformation may reprogram tumor metabolism and render tumor cells addicted to extracellular nutrients. Such nutrient addictions associated with oncogenic mutations may offer therapeutic opportunities; ho...
ORGANISM(S): Homo sapiens 
2016-07-01 | E-GEOD-60422 | biostudies-arrayexpress
ProteomicsProteomic analysis of urinary exosomes in cystinuria patients
Cystinuria is a rare renal genetic disease caused by mutations in cystine transporter genes and characterized by defective cystine reabsorption leading to kidney stones. In 14% of cases patients undergo nephrectomy, but given the difficulty to predict the evolution of the disease, the identification...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-03-01 | MSV000079546 | MassIVE
TranscriptomicsGenomic analysis of xCT-mediated regulatory network: identification of novel targets against AIDS-associated lymphoma
Kaposi’s sarcoma-associated herpesvirus (KSHV) is the etiological agent of primary effusion lymphoma (PEL), a rapidly progressing malignancy mostly arising in HIV-infected patients. Even under conventional chemotherapy, PEL continues to portend nearly 100% mortality within several months, which ur...
ORGANISM(S): Homo sapiens 
2015-11-23 | E-GEOD-65418 | biostudies-arrayexpress
TranscriptomicsBA-Methionine plus Cystine vs Cystine
Study of sulfur metabolism in BA 2 biologic replicates
ORGANISM(S): Brevibacterium aurantiacum 
2010-11-25 | E-GEOD-25418 | biostudies-arrayexpress
TranscriptomicsBA-Sulfate vs Cystine
Study of sulfur metabolism in BA 2 biologic replicates
ORGANISM(S): Brevibacterium aurantiacum 
2010-11-25 | E-GEOD-25419 | biostudies-arrayexpress
TranscriptomicsBA-Methionine plus Cystine vs Sulfate
Study of sulfur metabolism in BA 3 biologic replicates
ORGANISM(S): Brevibacterium aurantiacum 
2010-11-25 | E-GEOD-25420 | biostudies-arrayexpress
Sort   by:  
 Page size